A Descriptive Review and Meta-Regression Study of Demographic and Study Context Factors in US Clinical Trials of Cognitive Behavioral Interventions for Alcohol or Other Drug Use

Bibliographic Data

ID21646745
AuthorsDon-Pierre Burnett (School of Public Health, Brown University, Providence, Rhode Island, USA), Thomas A Trikalinos (0000-0002-3990-1848, School of Public Health, Brown University, Providence, Rhode Island, USA), Brian D Kiluk (0000-0002-1175-7979, Department of Psychiatry), Lara A Ray (0000-0002-5734-9444, University of California, Los Angeles), Lara Ray (University of California, Los Angeles), Chelsea Misquith (0000-0002-4274-0264, School of Public Health, Brown University, Providence, Rhode Island, USA), Molly Magill (0000-0001-5041-4664, School of Public Health, Brown University, Providence, Rhode Island, USA, corresponding author)
Year2024
Volume59
Issue12
Pages1711-1721
Publication date2024-10-14
Open AccessNo
TypeARTICLE
VenueSubstance Use & Misuse (JOURNAL)
Journal identifiersISSN: 1082-6084 • E-ISSN: 1532-2491
PublisherInforma UK Limited (PUBLISHER • GB)
DOI10.1080/10826084.2024.2369167
PMID38946162
OpenAlexW4400217473
LanguageEN
References cited62

Objectives. Cognitive-Behaviorally Based Interventions (CBIs) are evidence-based treatments for alcohol and other drug (AOD) use with potential variable effectiveness by population sub-groups. This study used evidence synthesis to examine treatment effect by demographic and study context factors in clinical trials of CBI for AOD. Methods. Studies were systematically identified, and their characteristics and outcome data were extracted and summarized. Standardized mean differences were calculated for within- and between-condition effects on substance use outcomes. Demographic and study context moderators were identified during data acquisition and several sensitivity analyses were conducted. Results. The sample included K = 29 trials and a total of 15 study-level moderators were examined. Information on participants’ age, biological sex, and race were reported in at least 26 trials, but information on gender identity, sexual orientation, and ethnicity were reported infrequently or in non-inclusive ways. The mean between-condition effect size was small and moderately heterogenous (d = 0.158, 95% CI = 0.079, 0.238, I2 = 46%) and the mean within-condition effect size was large and showed high heterogeneity (dz = 1.147, 95% CI = 0.811, 1.482, - I2 = 96%). The specific drug targeted in the study and whether biological assay-based outcomes were used moderated between-condition CBI efficacy and the inclusion of co-occurring mental health conditions and study publication date moderated within-condition CBI effects. Conclusions. Results provide preliminary data on study context factors associated with effect estimates in United States based clinical trials of CBI for AOD

Cognition · Meta-analysis · Meta-regression · Psychiatry · Psychological intervention · Behavioral Health and Interventions · Child and Adolescent Psychosocial and Emotional Development · Clinical Psychology · Medicine · Psychology · Substance Abuse Treatment and Outcomes

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