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Agreement, calibration, and failure of three large language models as high-stakes multimodal ospe graders

A comparative psychometric analysis

Bibliographic Data

ID21650342
AuthorsShahid Akhtar Akhund (0000-0003-1820-1276, Alfaisal University), Sadia Qazi (0009-0009-9275-8022, Alfaisal University, corresponding author), Muhammad Atif Mazhar (0009-0007-1588-3909, Alfaisal University), Aftab Ahmed Shaikh (0009-0009-4236-5933, Alfaisal University), Eshal Atif (0009-0006-7010-6910, Alfaisal University), Adeen Shaikh (0009-0009-7497-8662, Alfaisal University), Hassan Shaibah (0000-0002-3575-6460, Alfaisal University), Mohammed Alged Elsheikh Musa (0009-0005-9890-5469, Alfaisal University), Mohd Khirulnizam Musa (Alfaisal University), Sabiya N Qazi (0009-0004-4054-7809, Alfaisal University), Mateen A Khan (0000-0002-2300-4595, Alfaisal University), Akef Obeidat (0000-0002-4666-5118, Alfaisal University)
Year2026
Volume31
Issue1
Pages2684837-2684837
Publication date2026-12-31
Open AccessYes
TypeARTICLE
VenueMedical Education Online (JOURNAL)
Journal identifiersISSN: 1087-2981 • E-ISSN: 1087-2981
PublisherInforma UK Limited (PUBLISHER • GB)
DOI10.1080/10872981.2026.2684837
PMID42421433
OpenAlexW7167836367
LanguageEN
References cited63

Background Medical education faces increasing demand for scalable grading solutions. Large language models have been proposed as automated graders for high-stakes assessments, but evidence for their reliability in multimodal practical examinations remains limited.Methods This retrospective inter-rater reliability study compared three LLMs: ChatGPT-4o, Gemini 2.5 Flash, and Claude 3.5 Haiku with original human reference scores on 19 integrated anatomy, histology, and physiology objective structured practical examination items completed by 309 pre-medical students. Human reference scores were assigned during live summative grading by two content experts who divided items, with each item marked by one expert across all students; no human inter-rater reliability estimate was available. Items required simultaneous image interpretation and short-answer responses. Models were evaluated using zero-shot prompting reflecting deployment-realistic conditions. Agreement was assessed using Spearman's ρ, Cohen's κ, intraclass correlation coefficients, and Bland-Altman analysis. Item-level gap analysis compared student success rates with LLM performance across items.Results Rank-order correlations were strong across all models (ρ = 0.784–0.921), but categorical agreement diverged substantially. Pass/fail agreement ranged from 52.1% (ChatGPT; κ = 0.067, slight) to 84.1% (Claude; κ = 0.680, substantial). Bland-Altman analysis showed inconsistent systematic bias: Claude over-scored by +2.5 points, Gemini under-scored by −5.0 points, and ChatGPT by −10.0 points. Item-level gap analysis highlighted three recurring divergence patterns: non-standard histological staining, three-dimensional spatial reasoning from two-dimensional images, and semantic inflexibility in short-answer evaluation. The most extreme case was a pelvic three-dimensional model item on which 93.3% of students succeeded by human grading but all three LLMs assigned a mean score of zero.Conclusions Strong rank-order correlation alone does not support LLM grading for categorical decisions in high-stakes assessment contexts. LLMs may serve as assessment assistants for first-pass ranking and discrepancy flagging, but item-level human review of flagged discordances, error-profile monitoring, and preserved human authority over pass/fail decisions are required before high-stakes deployment

Categorical variable · Correlation · Human reliability · Inter-rater reliability · Intraclass correlation · Summative assessment · Artificial Intelligence in Healthcare and Education · Clinical Reasoning and Diagnostic Skills · Innovations in Medical Education

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