Ethical Challenges Posed by HIV-Vaccine Induced Seropositivity for the Informed Consent Process and HIV Testing Practices in Maputo City, Mozambique

Datos Bibliográficos

ID21747842
AutoresEmilia Fumane (0009-0009-4963-7962, Eduardo Mondlane University, autor de correspondencia), Khátia Munguambe (0000-0003-3888-5126, Eduardo Mondlane University), Graça Salomé (0000-0002-0533-0522, Eduardo Mondlane University), Troy D Moon (0000-0002-1637-829X, Tulane University Cecila Scott Weatherhead School of Public Health and Tropical Medicine), Elizabeth Heitman (0000-0002-4855-8551, Southwestern Medical Center), Esperança Sevene (0000-0001-9025-4052, Eduardo Mondlane University)
Año2026
Páginas15562646261448776-15562646261448776
Fecha de publicación2026-05-15
Peer ReviewedSí
Open AccessSí
TipoARTICLE
RevistaJournal of Empirical Research on Human Research Ethics (JOURNAL)
Identificadores de la revistaISSN: 1556-2646 • E-ISSN: 1556-2654
EditorialSAGE Publications (PUBLISHER • US)
DOI10.1177/15562646261448776
PMID42138353
OpenAlexW7161260326
IdiomaEN
Referencias citadas26

Mozambique has a robust HIV control program and currently conducts HIV vaccine trials. One measure of a vaccine's success is development of antibodies, the vaccine-induced seropositivity(VISP). This study assesses the understanding and practices regarding VISP from trial participants and healthcare providers, as well as ethical challenges encountered during the informed consent. We conducted in-depth, semi-structured interviews using open and closed-ended questions with three categories of participants: healthcare professionals [n = 26], researchers [n = 5] and trial participants [n = 20]. For qualitative data, content analysis was performed and thematic axes were assigned. For quantitative analysis, descriptive analysis was performed. Trial participants had a better understanding of VISP's implications than front-line healthcare professionals. 53.8% healthcare professionals interviewed, stated that they would test the trial participants using an HIV rapid test, and initiate antiretroviral therapy immediately if positive. VISP may result in HIV misdiagnoses for trial participants when its broader pratical implications are not well understood

Clinical trial · Confidentiality · Health care · Health professionals · Informed consent · Qualitative research · Thematic analysis · Biological Research and Disease Studies · Ethics in Clinical Research · HIV/AIDS Research and Interventions