Levosulpiride for Premature Ejaculation
A Systematic Review and Meta-Analysis
Bibliographic Data
| ID | 21748332 |
|---|---|
| Authors | Adina Arshad (Department of Zoology, Wildlife and Fisheries, Pir Mehr Ali Shah, Arid Agriculture University, Rawalpindi, Pakistan), Muhammad Irfan (0000-0003-1446-583X, Department of Zoology, Wildlife and Fisheries, Pir Mehr Ali Shah, Arid Agriculture University, Rawalpindi, Pakistan), Muhammad Inam (University of the Punjab), Nik Hazlina Nik Hussain (0000-0002-9476-062X, Universiti Sains Malaysia), Shaiful Bahari Ismail (0000-0002-2000-2332, Universiti Sains Malaysia) |
| Year | 2022 |
| Volume | 16 |
| Issue | 5 |
| Publication date | 2022-09-01 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | American Journal of Men s Health (JOURNAL) |
| Journal identifiers | ISSN: 1557-9883 • E-ISSN: 1557-9891 |
| Publisher | SAGE Publications (PUBLISHER • US) |
| DOI | 10.1177/15579883221124832 |
| Language | EN |
| References cited | 30 |
Premature ejaculation (PE) is one of the major causes of sexual dysfunction. Levosulpiride is an off-label medicine used to treat PE, but no review on its efficacy exists. A systematic review and meta-analysis was performed to determine the efficacy of levosulpiride in treating PE. Databases PubMed, Science Direct, and Google Scholar were searched. Randomized control trials (RCTs) comparing levosulpiride with placebo or other medicine were selected. Odds ratio (OR) of improved intravaginal ejaculation latency time (IELT) was calculated. A total of 97 articles were retrieved from database search, of which only four RCTs containing 203 men met the selection criteria. All four RCTs were included in systematic review while only two were included in meta-analysis. A high selection and detection bias was found in both of these studies. Meta-analysis also showed the odds of improving IELT in PE patients using levosulpiride to be significantly higher ( p 2 = 0%. Odds of improving IELT for > 5 min (500% improvement) were also significantly higher ( p 2 = 0%). The odds of improving IELT for > 1 min, but 2 = 0%). Levosulpiride improved IELT, but even so, limited studies are available on this topic. Additional research is thus required to support the present review’s findings
| Highly cited | No |
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