Association of the Vegf 2578C>A Polymorphism With Metabolic Syndrome and Erectile Dysfunction

Bibliographic Data

ID21748367
AuthorsChih-I Liu (0000-0001-9193-5749, Kaohsiung Medical University), Chia-Chu Liu (Department of Urology, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan), Chia‐Chu Liu (0000-0001-5797-4613, Kaohsiung Medical University), Shu‐Pin Huang (0000-0003-2968-6125, National Sun Yat-sen University), Shu-Pin Huang (Department of Urology, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan), Jiun‐Hung Geng (0000-0003-0610-1278, Kaohsiung Medical University, corresponding author), Yung‐Chin Lee (0000-0001-8193-403X, Kaohsiung Medical University), Yung-Chin Lee (Department of Urology, Kaohsiung Municipal Siaogang Hospital, Kaohsiung, Taiwan)
Year2024
Volume18
Issue5
Pages15579883241282385-15579883241282385
Publication date2024-09-01
Peer ReviewedYes
Open AccessYes
TypeARTICLE
VenueAmerican Journal of Men s Health (JOURNAL)
Journal identifiersISSN: 1557-9883 • E-ISSN: 1557-9891
PublisherSAGE Publications (PUBLISHER • US)
DOI10.1177/15579883241282385
PMID39397482
OpenAlexW4403404255
LanguageEN
References cited51

Accumulating evidence suggests a link between vascular endothelial growth factor (VEGF), erectile dysfunction (ED), and metabolic syndrome (Mets), possibly because VEGF can alter the physiological pathways involved in the regulation of endothelial cell proliferation. This study aimed to investigate the genetic susceptibility of VEGF 2578C>A polymorphism to the development of ED and Mets. Collected data included five-item International Index of Erectile Function (IIEF-5), components of Mets, and VEGF 2578C>A polymorphism. A total of 596 subjects from Kaohsiung with a mean age of 55.5 years were enrolled, data collection was done at our hospital. Individuals carrying the VEGF 2578 A allele (CA+AA genotypes) demonstrated a higher prevalence of ED compared to those with the CC genotype, with an adjusted odds ratio (OR) of 1.582 (95% confidence interval [95% CI] = 1.123–2.227, p value = 0.009) in multivariate binary regression analysis. Similarly, individuals carrying the VEGF 2578 A allele showed a higher prevalence of Mets compared to those with the CC genotype, with an adjusted OR of 2.461 (95% CI = 1.491–4.064, p value A polymorphism may serve as a common genetic susceptibility factor in the development of both disorders. Further research is warranted to evaluate the mechanisms underlying this association

Allele · Biology · Confidence interval · Erectile dysfunction · Gene · Genotype · Metabolic syndrome · Obesity · Odds ratio · Vascular endothelial growth factor · VEGF receptors · Hormonal and reproductive studies · Medicine · Menopause: Health Impacts and Treatments · Sexual function and dysfunction studies · Endocrinology · Genetics · Internal Medicine