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Oral Pre-exposure Prophylaxis Uptake and Acceptability Among Men Who Have Sex With Men

A Scoping Review of the Literature

Bibliographic Data

ID21748503
AuthorsPerez Livias Moyo (0009-0005-7501-0611, National University of Science and Technology, corresponding author), Wilfred Njabulo Nunu (0000-0001-8421-1478, National University of Science and Technology)
Year2023
Volume17
Issue5
Pages15579883231201729-15579883231201729
Publication date2023-09-01
Peer ReviewedYes
Open AccessYes
TypeARTICLE
VenueAmerican Journal of Men s Health (JOURNAL)
Journal identifiersISSN: 1557-9883 • E-ISSN: 1557-9891
PublisherSAGE Publications (PUBLISHER • US)
DOI10.1177/15579883231201729
PMID37776162
OpenAlexW4387210121
LanguageEN
Citations received6
References cited61

Despite the global effort to end the human immunodeficiency virus (HIV) and acquired immunodeficiency syndrome (AIDS) epidemic as a global threat by 2030, the rate of new HIV infections worldwide remains unacceptably high among men who have sex with men, hence the need to use pre-exposure prophylaxis (PrEP) to reduce the risk of HIV infection. This population has an increased risk of getting HIV; thus, it is imperative to assess the uptake and acceptability of PrEP. This study investigated the willingness, availability, accessibility, and knowledge and identified barriers and facilitators to using PrEP among this population. A scoping literature review search was conducted on research papers published in English and focused on men who have sex with men and their use of PrEP. These were independently screened and coded. Of about 1,202 literature sources, 55 were included in the study. Findings reported that the uptake and acceptability of PrEP were influenced by knowledge and perception of being high-risk. Generally, PrEP uptake and understanding were high in North America, Latin America, and Europe and low in Asia and Africa. Low uptake and acceptability have been largely attributed to fear of side effects, societal stigma, cost, and perception of not being at risk. Noted facilitators to PrEP use include education, availability of free pills, support groups, and friendly health care facilities. Health intervention programs to increase the use of PrEP must be backed by appropriate legal and regulatory frameworks

Environmental health · Family medicine · Men who have sex with men · Perception · Pill · Population · Pre-exposure prophylaxis · Psychiatry · Risk perception · HIV, Drug Use, Sexual Risk · HIV/AIDS Research and Interventions · Medicine · Nursing · Psychology · Sex work and related issues · Gerontology

  • Exploring Barriers and Facilitators That Influence Uptake of Oral Pre-Exposure Prophylaxis Among Men Who Have Sex With Men in Bulawayo, Zimbabwe

    Open Access•Perez Livias Moyo, Wilfred Njabulo Nunu•American Journal of Men s Health•2024

  • Awareness and acceptability of long-acting injectable pre-exposure prophylaxis for HIV prevention among female students at tertiary learning institutions

    Open Access•Martin Kampamba, Pumulo Munawai et al.•BMC Public Health•2025

  • Interest in Oral Pre-exposure Prophylaxis Among Men Who Have Sex with Men and Transfeminine Persons in HPTN 075, a Multi-center HIV Prevention Study in Sub-Saharan Africa (2015–2017)

    Open Access•Joseph Orinda, Joseph O Orinda et al.•AIDS and Behavior•2024

  • Do community-level factors play a role in HIV self-testing uptake, linkage to services and HIV-related outcomes? A mixed methods study of community-led HIV self-testing in rural Zimbabwe

    Open Access•Mary K Tumushime, Nancy Ruhode et al.•PLOS Global Public Health•2025

  • Criminalisation, stigma, and survival

    Open Access•Roberta E Emetu, Cecilia E Dagher•African Journal of AIDS Research•2026

  • HIV pre-exposure prophylaxis use with casual partners among men who have sex with men in Switzerland

    Open Access•Benedikt Hassler, Sibylle Nideröst et al.•AIDS Care•2026

  • A Global Estimate of the Acceptability of Pre-exposure Prophylaxis for HIV Among Men Who have Sex with Men

    Open Access•Peng Peng, Shu Su et al.•AIDS and Behavior•2018

  • Uptake of pre-exposure prophylaxis, sexual practices, and HIV incidence in men and transgender women who have sex with men

    Open Access•Robert M Grant, Peter L Anderson et al.•The Lancet Infectious Diseases•2014

  • Acceptability of pre-exposure prophylaxis as an HIV prevention strategy

    Open Access•Jerome T Galea, Janni J Kinsler et al.•International Journal of STD & AIDS•2011

  • Acceptability of PrEP Uptake Among Racially/Ethnically Diverse Young Men Who Have Sex With Men

    Rafael Perez‐figueroa, Rafael E Pérez-Figueroa et al.•AIDS Education•2015

  • Title unavailable

    Open Access•null null•Philosophy study•2016

  • Sexual and Gender Minorities Inclusion and Uptake of Sexual and Reproductive Health Services

    Open Access•Methembe Yotamu Khozah, Wilfred Njabulo Nunu•American Journal of Men s Health•2023

  • Pre-exposure prophylaxis among men who have sex with men in Côte d’Ivoire

    Open Access•Souleymane Diabaté, O Kra et al.•AIDS Care•2021

  • Awareness and Acceptability of pre-exposure prophylaxis (PrEP) among gay, bisexual and other men who have sex with men (GBMSM) in Kenya

    Adedotun Ogunbajo, Augustine W Kang et al.•AIDS Care•2019

  • Knowledge and Acceptability of HIV pre-exposure prophylaxis (PrEP) among men who have sex with men (MSM) in Ghana

    Adedotun Ogunbajo, Natalie M Leblanc et al.•AIDS Care•2020

  • Behavioral interventions to reduce HIV risk behavior for MSM and transwomen in Southeast Asia

    Open Access•Adi Nugroho, Vicki Erasmus et al.•AIDS Care•2017

  • Acceptability and willingness to use HIV pre-exposure prophylaxis among HIV-negative men who have sex with men in Switzerland

    Open Access•Daniel Gredig, Franziska Uggowitzer et al.•AIDS Care•2016

  • A Profilaxia Pré-Exposição ao HIV (PrEP) entre homens que fazem sexo com homens

    Open Access•Lorruan Alves Dos Santos, Alexandre Grangeiro et al.•Ciência & Saúde Coletiva•2022

  • HIV Pre-Exposure Prophylaxis (PrEP) among men who have sex with men

    Open Access•Lorruan Alves Dos Santos, Alexandre Grangeiro et al.•Ciência & Saúde Coletiva•2022

  • Acceptability of Pre-Exposure Prophylaxis and Non-Occupational Post-Exposure Prophylaxis among Men Who Have Sex with Men in Guilin, China

    Open Access•Lingmi Zhou, Sawitri Assanangkornchai et al.•International Journal of…•2022

  • Knowledge, Attitudes and Practices Regarding Pre-Exposure Prophylaxis (PrEP) in a Sample of Italian Men Who Have SEX with MEN (MSM)

    Open Access•Gianluca Voglino, Maria Rosaria Gualano et al.•International Journal of…•2021

  • HIV prevention needs for men who have sex with men in Swaziland

    Open Access•Bhekie Sithole•African Journal of AIDS Research•2017

  • Acceptability of pre-exposure prophylaxis for HIV prevention

    Open Access•Carin Ahouada, Souleymane Diabaté et al.•BMC Public Health•2020

  • Community perspectives on barriers and challenges to HIV pre-exposure prophylaxis access by men who have sex with men and female sex workers access in Nigeria

    Open Access•Godwin Emmanuel, Morenike O Folayan et al.•BMC Public Health•2020

  • HIV Pre-exposure Prophylaxis (PrEP) Uptake and Retention Among Men Who Have Sex with Men in a Community-Based Sexual Health Clinic

    Open Access•J Carlo Hojilla, David Vlahov et al.•AIDS and Behavior•2017

  • Perceptions and Practicalities Influencing Pre-exposure Prophylaxis Adherence Among Men Who Have Sex with Men in England

    Open Access•Dora Arnold-Forster, Robert Horne et al.•AIDS and Behavior•2022

  • Challenges with PrEP Uptake and Adherence Among Gay, Bisexual, and Other Men Who Have Sex with Men in Kisumu, Kenya

    Open Access•Susan M Graham, Duncan Okall et al.•AIDS and Behavior•2022

  • Understanding PrEP Acceptability Among Priority Populations

    Open Access•Radhika Sundararajan, Monique A Wyatt et al.•AIDS and Behavior•2022

  • HIV Testing, Knowledge and Willingness to Use PrEP Among Partnered Men Who Have Sex With Men in South Africa and Namibia

    Open Access•Rob Stephenson, Lynae A Darbes et al.•AIDS and Behavior•2021

  • Optimizing Uptake of Long-Acting Injectable Pre-exposure Prophylaxis for HIV Prevention for Men Who Have Sex with Men

    Open Access•Lorraine T Dean, Zachary Predmore et al.•AIDS and Behavior•2023

  • Gearing up for PrEP in the Middle East and North Africa

    Erik D Storholm, Matt G Mutchler et al.•Behavioral Medicine•2019

Unique citing works6
Citations per year3
Citation span2024 - 2026 (3)
Citation velocitycurrent
Highly citedNo
Citation typesNeutral: 5

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