Age-Dependent Effects of Homocysteine on Erectile Dysfunction Risk Among U.S. Males
A NHANES Analysis
Bibliographic Data
| ID | 21748620 |
|---|---|
| Authors | Xuewen Diao (0009-0009-1595-4900, First Affiliated Hospital of Henan University), Chenming Zhang (0000-0002-6770-5334, First Affiliated Hospital of Henan University), Zulong Wang (0000-0002-5902-8433, First Affiliated Hospital of Henan University, corresponding author) |
| Year | 2024 |
| Volume | 18 |
| Issue | 5 |
| Pages | 15579883241278065-15579883241278065 |
| Publication date | 2024-09-01 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | American Journal of Men s Health (JOURNAL) |
| Journal identifiers | ISSN: 1557-9883 • E-ISSN: 1557-9891 |
| Publisher | SAGE Publications (PUBLISHER • US) |
| DOI | 10.1177/15579883241278065 |
| PMID | 39378081 |
| OpenAlex | W4403215085 |
| Language | EN |
| Citations received | 1 |
| References cited | 31 |
Erectile dysfunction (ED) is a common problem that seriously impacts men’s quality of life and mental health. Earlier studies have indicated that homocysteine (HCY) levels might be linked to the risk of ED, although these studies are limited by small sample sizes and insufficient correction for confounding factors. This study uses data from the 2001-2004 National Health and Nutrition Examination Survey (NHANES) to evaluate the relationship between HCY levels and ED risk in U.S. adult males. The analysis involved using a weighted generalized linear model to assess main effects and restricted cubic splines (RCS) to explore nonlinear relationships. Results showed that the association between HCY and ED was not statistically significant after adjusting for covariates. However, interaction analyses between age and the HCY-ED relationship showed that as age increases, the impact of HCY on ED strengthens. Based on this, subgroup analysis by age was carried out, revealing that in people aged 50 and above, HCY levels were significantly positively correlated with ED, especially when HCY levels exceeded 9.22 μmol/L, significantly increasing the risk of ED. Sensitivity analysis further confirmed the robustness of these findings. This study indicates that controlling HCY levels, especially in middle-aged and older men, might help prevent and treat ED, providing a foundation for future preventive strategies
Confounding · Environmental health · Erectile dysfunction · Homocysteine · National Health and Nutrition Examination Survey · Population · Demography · Folate and B Vitamins Research · Medicine · Sexual function and dysfunction studies · Urinary Bladder and Prostate Research · Gerontology · Internal Medicine
| Unique citing works | 1 |
|---|---|
| Citations per year | 1 |
| Citation span | 2026 - 2026 (1) |
| Citation velocity | current |
| Highly cited | No |
| Citation types | Neutral: 1 |