Microbicide trials for preventing HIV/Aids in South Africa
Phase II trial participants' experiences and psychological needs
Bibliographic Data
| ID | 2177459 |
|---|---|
| Authors | Annalie Pistorius (Health Professions Council of South Africa (HPCSA)), A G Prof Pistorius (0000-0003-3378-9805), Janneke Van De Wijgert (0000-0003-2728-4560), Mohlatlego Sebola (Health Professions Council of South Africa (HPCSA)), Barbara Friedland (0000-0002-5041-3634, Population Council), Evelyn Nagel (Health Professions Council of South Africa (HPCSA)), Cathleen Bokaba (Sefako Makgatho Health Sciences University), Anwar Hoosen, A A Hoosen (Sefako Makgatho Health Sciences University) |
| Year | 2004 |
| Volume | 1 |
| Issue | 2 |
| Pages | 78-86 |
| Publication date | 2004-08-01 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | SAHARA-J Journal of Social Aspects of HIV/AIDS (JOURNAL) |
| Journal identifiers | ISSN: 1729-0376 • E-ISSN: 1813-4424 |
| Publisher | Informa UK Limited (PUBLISHER • GB) |
| DOI | 10.1080/17290376.2004.9724830 |
| PMID | 17601013 |
| OpenAlex | W1996092150 |
| Language | EN |
| Citations received | 5 |
| References cited | 18 |
The Microbicide Division of the Department of Medical Microbiology at MEDUNSA, South Africa, recently completed a phase II expanded safety trial of the candidate microbicide Carraguard. A microbicide is a vaginal product that women might use, if proven safe and effective, to protect themselves from HIV and possibly other sexually transmitted infections (STIs). The study participants were from Ga-Rankuwa and its neighbouring areas, an historically disadvantaged residential township near Pretoria. We conducted six focus group discussions with phase II trial participants to evaluate their experiences with trial participation and their psychological needs. Participants spontaneously talked about their experiences with the study gel and speculum examinations. They felt that they had received high quality medical care. They indicated that their personal hygiene and knowledge of the female reproductive system, HIV and other STIs had improved, which helped their familie and empowered them as women. Participants valued being able to discuss their anxiety about HIV/AIDS wit study staff. They felt that the study provided them with a supportive environment in which their personal problems (not necessarily restricted to HIV/AIDS) could be addressed. Some recommended that the study staf improve their professionalism and punctuality. They suggested the formation of participant support groups, an expressed a preference to remain involved in the trial. Some participants appeared to have become dependent o services provided during the trial. We have taken the results of these focus group discussions into account during planning for a phase III efficacy trial of Carraguard to be conducted in the same and other similar communities
Environmental health · Family medicine · Focus group · Microbicide · Microbicides for sexually transmitted diseases · Population · Adolescent Sexual and Reproductive Health · Focus Groups and Qualitative Methods · HIV/AIDS Research and Interventions · Medicine
Ethical challenges in efficacy trials of vaginal microbicides for HIV prevention
"Why don't they just tell me straight, why allocate it?" The struggle to make sense of participating in a randomised controlled trial
Men's attitudes towards a potential vaginal microbicide in Zimbabwe, Mexico and the USA
| Unique citing works | 5 |
|---|---|
| Citations per year | 0,25 |
| Citation span | 2006 - 2020 (15) |
| Citation velocity | historical |
| Highly cited | No |
| Citation types | Neutral: 5 |