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A case study in research ethics and accelerated vaccine development

Bibliographic Data

ID21787643
AuthorsKlaus Leisinger (Global Values Alliance, Switzerland), Doris Schroeder (0000-0002-3633-2758, University of Lancashire, corresponding author)
Year2024
Volume20
Issue4
Pages847-856
Publication date2024-10-01
Peer ReviewedYes
Open AccessYes
TypeARTICLE
VenueResearch Ethics (JOURNAL)
Journal identifiersISSN: 1747-0161 • E-ISSN: 2047-6094
PublisherSAGE Publications (PUBLISHER • US)
DOI10.1177/17470161241251597
OpenAlexW4396530198
LanguageEN
Citations received1
References cited11

The COVID-19 pathogen led to a fast expanding pandemic because it proved lethal in certain populations but could be transmitted by persons who appeared healthy. As a result, researchers came under unprecedented time pressure to develop a vaccine. This case study focuses on the first COVID-19 vaccine, which was approved for use in humans, known as Comirnaty, the BioNTech-Pfizer COVID-19 vaccine or Vaccine BNT162b2. With the benefit of hindsight, we show how close collaboration with regulators and trust-based decisions meant that the race for a COVID-19 vaccine was won without purposefully infecting healthy participants with an infectious agent that can cause severe illness or death and for which no rescue therapy had existed

2019-20 coronavirus outbreak · Family medicine · Hindsight bias · Outbreak · Pandemic · Pathology · Medicine · Psychology · Psychology of Moral and Emotional Judgment · SARS-CoV-2 and COVID-19 Research · Vaccine Coverage and Hesitancy · Virology

  • Reimagining Research Ethics Through Local Knowledge and Leadership

    Open Access•Naw May Lyar Soe, Saw Than Lwin et al.•Asia Pacific Viewpoint•2026

  • Covid-19 human challenge trials and randomized controlled trials

    Open Access•Charles Weijer•Research Ethics•2024

Unique citing works1
Citations per year1
Citation span2026 - 2026 (1)
Citation velocitycurrent
Highly citedNo
Citation typesNeutral: 1

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