Child mortality associated with maternal HIV status

A retrospective analysis in Rwanda, 2005-2015

Dados Bibliográficos

ID21879430
AutoresEric Remera (0000-0002-6084-8877, Swiss Tropical and Public Health Institute, autor correspondente), Frédérique Chammartin (0000-0001-8959-2724, University of Basel), Sabin Nsanzimana (0000-0002-5946-0015, University of Global Health Equity), Jamie I Forrest (0000-0002-8900-7350, University of British Columbia), Gerald E Smith (Cytel, Vancouver, British Columbia, Canada), Placidie Mugwaneza (Rwanda Biomedical Center), Samuel S Malamba (0000-0001-8087-8849, Uganda Virus Research Institute), Muhammed Semakula (0000-0002-9076-4922, University of Kigali), Jeanine Condo (0000-0002-8177-6286, Tulane University), Jeanine U Condo (National University of Rwanda School of Public Health, Kigali, Rwanda), Nathan Ford (0000-0001-8752-9078, University of Cape Town), David J Riedel (0000-0002-7399-6406, University of Maryland, Baltimore), Marie Paul Nisingizwe (0000-0003-2702-5841, University of British Columbia), Agnes Binagwaho (0000-0002-6779-3151, University of Global Health Equity), Edward J Mills (0000-0003-3120-9694, Impact), Heiner C Bucher (0000-0002-0131-7873, University of Basel), Heiner Bucher (University of Basel, Basel, Switzerland)
Ano2021
Volume6
Fascículo5
Páginase004398
Data de publicação2021-05-01
Peer ReviewedSim
Open AccessSim
TipoARTICLE
PeriódicoBMJ Global Health (JOURNAL)
Identificadores do periódicoISSN: 2059-7908 • E-ISSN: 2059-7908
EditoraBMJ (PUBLISHER • GB)
DOI10.1136/bmjgh-2020-004398
PMID33975886
OpenAlexW3163897097
IdiomaEN
Referências citadas26

INTRODUCTION: Child mortality remains highest in regions of the world most affected by HIV/AIDS. The aim of this study was to assess child mortality rates in relation to maternal HIV status from 2005 to 2015, the period of rapid HIV treatment scale-up in Rwanda. METHODS: We used data from the 2005, 2010 and 2015 Rwanda Demographic Health Surveys to derive under-2 mortality rates by survey year and mother's HIV status and to build a multivariable logistic regression model to establish the association of independent predictors of under-2 mortality stratified by mother's HIV status. RESULTS: In total, 12 010 live births were reported by mothers in the study period. Our findings show a higher mortality among children born to mothers with HIV compared with HIV negative mothers in 2005 (216.9 vs 100.7 per 1000 live births) and a significant reduction in mortality for both groups in 2015 (72.0 and 42.4 per 1000 live births, respectively). In the pooled reduced multivariable model, the odds of child mortality was higher among children born to mothers with HIV, (adjusted OR, AOR 2.09; 95% CI 1.57 to 2.78). The odds of child mortality were reduced in 2010 (AOR 0.69; 95% CI 0.59 to 0.81) and 2015 (AOR 0.35; 95% CI 0.28 to 0.44) compared with 2005. Other independent predictors of under-2 mortality included living in smaller families of 1-2 members (AOR 5.25; 95% CI 3.59 to 7.68), being twin (AOR 4.93; 95% CI 3.51 to 6.92) and being offspring from mothers not using contraceptives at the time of the survey (AOR 1.6; 95% CI 1.38 to 1.99). Higher education of mothers (completed primary school: (AOR 0.74; 95% CI 0.64 to 0.87) and secondary or higher education: (AOR 0.53; 95% CI 0.38 to 0.74)) was also associated with reduced child mortality. CONCLUSIONS: This study shows an important decline in under-2 child mortality among children born to both mothers with and without HIV in Rwanda over a 10-year span

Child mortality · Environmental health · Logistic regression · Mortality rate · Odds · Odds ratio · Population · Public health · Demography · Global Maternal and Child Health · HIV/AIDS Impact and Responses · HIV/AIDS Research and Interventions · Medicine · Immunology · Internal Medicine · Pediatrics