Mass azithromycin administration
Considerations in an increasingly resistant world
Bibliographic Data
| ID | 21880293 |
|---|---|
| Authors | Yogesh Hooda (0000-0002-7181-9254, MRC Laboratory of Molecular Biology), Arif Mohammad Tanmoy (0000-0002-7769-8035, Child Health Research Foundation), Mohammad Saiful Islam Sajib (0000-0002-3962-9805, Child Health Research Foundation), Senjuti Saha (0000-0001-6087-6766, Child Health Research Foundation, corresponding author) |
| Year | 2020 |
| Volume | 5 |
| Issue | 6 |
| Pages | e002446 |
| Publication date | 2020-06-01 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | BMJ Global Health (JOURNAL) |
| Journal identifiers | ISSN: 2059-7908 • E-ISSN: 2059-7908 |
| Publisher | BMJ (PUBLISHER • GB) |
| DOI | 10.1136/bmjgh-2020-002446 |
| PMID | 32522739 |
| OpenAlex | W3033492293 |
| Language | EN |
| References cited | 15 |
► Recent studies have shown that mass administration of azithromycin in some areas can lead to reduction in childhood mortality, which in turn has led to additional large-scale trials in many parts of the world.► We provide evidence for the emergence of novel azithromycin resistance mechanisms in common bacterial pathogens like Salmonella, arguing that the appealing positive effects of mass drug administration might diminish with increasing azithromycin resistance.► While a silver bullet against childhood mortality is highly desirable, given the alarming rise in antimicrobial resistance and the drying pipeline of novel drugs, the opportunity costs of mass administration should be considered with utmost caution.► Future studies and trials of mass azithromycin administration should include methods for early detection of azithromycin resistance such that preventative measures can be implemented, in case azithromycin resistance begins to spread
Antibiotic resistance · Antibiotics · Azithromycin · Biology · Drug resistance · Environmental health · Food and drug administration · Intensive care medicine · Mass drug administration · Political science · Antibiotic Resistance in Bacteria · Antibiotic Use and Resistance · Medicine · Pneumonia and Respiratory Infections · Microbiology
| Citation velocity | historical |
|---|---|
| Highly cited | No |