Research priorities for the secondary prevention and management of acute rheumatic fever and rheumatic heart disease

A National Heart, Lung, and Blood Institute workshop report

Bibliographic Data

ID21880673
AuthorsGanesan Karthikeyan (0000-0002-2073-2917, All India Institute of Medical Sciences), David Watkins (0000-0002-3930-5990, University of Washington, corresponding author), Gene Bukhman (0000-0003-4500-7903, Brigham and Women's Hospital), Madeleine W Cunningham (0000-0001-8122-728X, University of Oklahoma Health Sciences Center), John S Haller (0009-0000-6694-6200, National Heart Lung and Blood Institute), John Haller (National Heart, Lung, and Blood Institute, Bethesda, Maryland, USA), Mary Y Masterson (0000-0002-3369-9183, National Heart Lung and Blood Institute), George A Mensah (0000-0002-0387-5326, National Heart Lung and Blood Institute), Ana Olga Mocumbi (0000-0002-9564-2860, Eduardo Mondlane University), Babu Muhamed (0000-0003-4832-0671, University of Tennessee Health Science Center), Emmy Okello (0000-0002-6109-0092, Uganda Management Institute), Nona Sotoodehnia (0000-0002-2705-6237, University of Washington), Tafadzwa Machipisa (0000-0002-4882-9067, University of Cape Town), Anna Ralph (0000-0002-2253-5749, Charles Darwin University), Rosemary Wyber (0000-0003-3904-9269, Australian Institute of Aboriginal and Torres Strait Islander Studies), Andrea Beaton (0000-0002-4963-355X, Cincinnati Children's Hospital Medical Center)
Year2023
Volume8
IssueSuppl 9
Pagese012468
Publication date2023-10-01
Peer ReviewedYes
Open AccessYes
TypeARTICLE
VenueBMJ Global Health (JOURNAL)
Journal identifiersISSN: 2059-7908 • E-ISSN: 2059-7908
PublisherBMJ (PUBLISHER • GB)
DOI10.1136/bmjgh-2023-012468
PMID37914183
OpenAlexW4388142602
LanguageEN
Citations received1
References cited54

Secondary prevention of acute rheumatic fever (ARF) and rheumatic heart disease (RHD) involves continuous antimicrobial prophylaxis among affected individuals and is recognised as a cornerstone of public health programmes that address these conditions. However, several important scientific issues around the secondary prevention paradigm remain unresolved. This report details research priorities for secondary prevention that were developed as part of a workshop convened by the US National Heart, Lung, and Blood Institute in November 2021. These span basic, translational, clinical and population science research disciplines and are built on four pillars. First, we need a better understanding of RHD epidemiology to guide programmes, policies, and clinical and public health practice. Second, we need better strategies to find and diagnose people affected by ARF and RHD. Third, we urgently need better tools to manage acute RF and slow the progression of RHD. Fourth, new and existing technologies for these conditions need to be better integrated into healthcare systems. We intend for this document to be a reference point for research organisations and research sponsors interested in contributing to the growing scientific community focused on RHD prevention and control

Acute rheumatic fever · Cornerstone · Health care · Heart disease · Intensive care medicine · Pathology · Political science · Public health · Rheumatic fever · Translational research · Bacterial Identification and Susceptibility Testing · Medicine · Nursing · Streptococcal Infections and Treatments · Epidemiology · Immunology

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