Building a national framework for multicentre research and clinical trials
Experience from the Nigeria Implementation Science Alliance
Bibliographic Data
There is limited capacity and infrastructure in sub-Saharan Africa to conduct clinical trials for the identification of efficient and effective new prevention, diagnostic and treatment modalities to address the disproportionate burden of disease. This paper reports on the process to establish locally driven infrastructure for multicentre research and trials in Nigeria known as the Nigeria Implementation Science Alliance Model Innovation and Research Centres (NISA-MIRCs). We used a participatory approach to establish a research network of 21 high-volume health facilities selected from all 6 geopolitical zones in Nigeria capable of conducting clinical trials, implementation research using effectiveness-implementation hybrid designs and health system research. The NISA-MIRCs have a cumulative potential to recruit 60 000 women living with HIV and an age-matched cohort of HIV-uninfected women. We conducted a needs assessment, convened several stakeholder outreaches and engagement sessions, and established a governance structure. Additionally, we selected and trained a core research team, developed criteria for site selection, assessed site readiness for research and obtained ethical approval from a single national institutional review board. We used the Exploration, Preparation, Implementation, Sustainment framework to guide our reporting of the process in the development of this network. The NISA-MIRCs will provide a nationally representative infrastructure to initiate new studies, support collaborative research, inform policy decisions and thereby fill a significant research infrastructure gap in Africa’s most populous country
Alliance · Business · Capacity building · Clinical trial · Economic growth · Environmental planning · Environmental resource management · Geography · Political science · Public relations · Stakeholder · Stakeholder engagement · Ethics in Clinical Research · Health Policy Implementation Science · Health Systems, Economic Evaluations, Quality of Life · Medicine
Building Research Capacity in Africa
Use of concept mapping to characterize relationships among implementation strategies and assess their feasibility and importance
Systematic review of the Exploration, Preparation, Implementation, Sustainment (Epis) framework
Observational research methods. Research design II
A refined compilation of implementation strategies
Research electronic data capture (Redcap)—A metadata-driven methodology and workflow process for providing translational research informatics support
The Redcap consortium
Conducting clinical research in a resource-constrained setting
Pregnancy cohorts and biobanking in sub-Saharan Africa
Implementing the routine immunisation data module and dashboard of DHIS2 in Nigeria, 2014–2019
The challenge of bridging the gap between researchers and policy makers
Feasibility of a large cohort study in sub-Saharan Africa assessed through a four-country study
The protocol of a population-based prospective cohort study in southwest of Iran to analyze common non-communicable diseases
Effectiveness and cost-effectiveness of neuromuscular exercise and back care counseling in female healthcare workers with recurrent non-specific low back pain
WhatsApp Groups in Social Research
Effectiveness-implementation Hybrid Designs
Exploring the acceptability of Option B plus among HIV-positive Nigerian women engaged and not engaged in the prevention of mother-to-child transmission of HIV cascade
| Unique citing works | 3 |
|---|---|
| Citations per year | 1 |
| Citation span | 2023 - 2025 (3) |
| Citation velocity | recent |
| Highly cited | No |
| Citation types | Neutral: 3 |