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Acceptability and feasibility of glucose-6-phosphate dehydrogenase (G6PD) testing using SD Biosensor by village malaria workers in Cambodia

A qualitative study

Bibliographic Data

ID21881591
AuthorsSarah A Cassidy-Seyoum (0000-0003-0802-347X, Charles Darwin University), Bipin Adhikari (0000-0001-8981-3910, Angkor Hospital for Children), Keoratha Chheng (Mahidol Oxford Tropical Medicine Research Unit), Phal Chanpheakdey (Mahidol Oxford Tropical Medicine Research Unit), Agnes Meershoek (0000-0002-1642-8672, Department of Health), Michelle S Hsiang (0000-0003-1217-2742, University of California, San Francisco), Lorenz Von Seidlein (0000-0002-0282-6469, Angkor Hospital for Children), Rupam Tripura (0000-0002-3281-9702, Angkor Hospital for Children), Benedikt Ley (0000-0002-5734-0845, Charles Darwin University), Richard N Price (0000-0003-2000-2874, Angkor Hospital for Children), Dysoley Lek (Cambodia National Malaria Center), Lek Dysoley (National Center for Parasitology, Entomology and Malaria Control, Phnom Penh, Cambodia), Kamala Thriemer (0000-0001-7536-7497, Charles Darwin University), Nora Engel (0000-0002-1823-3908, Charles Darwin University)
Year2025
Volume10
Issue6
Pagese019615
Publication date2025-06-01
Peer ReviewedYes
Open AccessYes
TypeARTICLE
VenueBMJ Global Health (JOURNAL)
Journal identifiersISSN: 2059-7908 • E-ISSN: 2059-7908
PublisherBMJ (PUBLISHER • GB)
DOI10.1136/bmjgh-2025-019615
PMID40527529
OpenAlexW4411383909
LanguageEN
References cited36

Introduction Plasmodium vivax is the predominant cause of malaria in the Greater Mekong Subregion. To ensure safe treatment with primaquine, point-of-care glucose-6-phosphate dehydrogenase (G6PD) testing was rolled out in Cambodia at the health facility level, although most malaria patients are diagnosed in the community. The current study aims to explore the acceptability and feasibility of implementing community-level G6PD testing in Cambodia. Methods Semistructured interviews and focus group discussions (FGD) were conducted. Across eight study sites in three provinces, 142 respondents, including policymakers, programme officers, healthcare providers and patients, participated in 67 interviews and 19 FGDs in 2022 and 2023. Data were analysed thematically using an adapted framework derived from Bowen et al ’s feasibility framework and Sekhon et al ’s acceptability framework. Results All stakeholders attributed value to the intervention. Acknowledging an intervention’s different values can help discern policy implications for an intervention’s successful implementation. Building and maintaining confidence in the device, end users, infrastructure and health systems were found to be key elements of acceptability. In general, health centre workers and village malaria workers (VMWs) had confidence that VMWs could conduct the test and administer treatment given appropriate initial training, monthly refresher training and the test’s repeated use. More is required to build policymakers’ confidence, while some implementation challenges, including the test’s regulatory approval, stability above 30°C and cost, need to be overcome. Conclusion Implementation of G6PD testing at the community level in Cambodia is an acceptable and potentially feasible option but requires addressing implementation challenges and building and maintaining confidence among stakeholders

Business · Chloroquine · Economic growth · Economics · Environmental health · Family medicine · Focus group · Health care · Malaria · Primaquine · Psychological intervention · Clinical Laboratory Practices and Quality Control · Malaria Research and Control · Medicine · Neonatal Health and Biochemistry · Nursing · Marketing

  • Acceptability of healthcare interventions

    Open Access•Mandeep Sekhon, Martin Cartwright et al.•BMC Health Services Research•2017

  • How We Design Feasibility Studies

    Open Access•Deborah J Bowen, Matthew W Kreuter et al.•American Journal of Preventive…•2009

  • Implementation of Glucose-6-Phosphate Dehydrogenase (G6PD) testing for Plasmodium vivax case management, a mixed method study from Cambodia

    Open Access•Sarah A Cassidy-Seyoum, Keoratha Chheng et al.•PLOS Global Public Health•2024

  • Bringing the state into the clinic? Incorporating the rapid diagnostic test for malaria into routine practice in Tanzanian primary healthcare facilities

    Open Access•Eleanor Hutchinson, Hugh Reyburn et al.•Global Public Health•2015

  • Malaria in Cambodia

    Open Access•Srean Chhim, Patrice Piola et al.•International Journal of…•2021

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Highly citedNo
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