Estimated health benefits, costs and cost-effectiveness of eliminating industrial trans - fatty acids in Nigeria

Cost-effectiveness analysis

Bibliographic Data

ID21881602
AuthorsMatti Marklund (0000-0002-3320-796X, Uppsala University, corresponding author), Léopold Ndemnge Aminde (0000-0003-2787-7518, Griffith University), Mary Njeri Wanjau (0000-0002-4588-7528, Griffith University), Boni Maxime Ale (0000-0002-8449-3310, University of Abuja Teaching Hospital), Adedayo E Ojo (0000-0001-7062-698X, University Medical Center Utrecht), Clementina Ebere Okoro (0009-0009-2778-2210, National Primary Health Care Development Agency), Abimbola Adegboye (0000-0002-9978-8445, National Agency for the Control of AIDS), Liping Huang (0000-0003-3073-7698, The George Institute for Global Health), Lennert Veerman (0000-0002-3206-8232, Griffith University), Jason H Wu (0000-0003-2073-3562, UNSW Sydney), Mark D Huffman (0000-0001-7412-2519, Washington University in St. Louis), Dike Ojji (0000-0002-2084-1988, University of Abuja Teaching Hospital), Dike B Ojji (Cardiovascular Research Unit, University of Abuja Teaching Hospital, Gwagwalada, Abuja, Nigeria)
Year2024
Volume9
Issue4
Pagese014294
Publication date2024-04-01
Open AccessYes
TypeARTICLE
VenueBMJ Global Health (JOURNAL)
Journal identifiersISSN: 2059-7908 • E-ISSN: 2059-7908
PublisherBMJ (PUBLISHER • GB)
DOI10.1136/bmjgh-2023-014294
PMID38631705
OpenAlexW4394883479
LanguageEN
References cited29

Introduction Nigeria is committed to reducing industrial trans- fatty acids (iTFA) from the food supply, but the potential health gains, costs and cost-effectiveness are unknown. Methods The effect on ischaemic heart disease (IHD) burden, costs and cost-effectiveness of a mandatory iTFA limit (≤2% of all fats) for foods in Nigeria were estimated using Markov cohort models. Data on demographics, IHD epidemiology and trans- fatty acid intake were derived from the 2019 Global Burden of Disease Study. Avoided IHD events and deaths; health-adjusted life years (HALYs) gained; and healthcare, policy implementation and net costs were estimated over 10 years and the population’s lifetime. Incremental cost-effectiveness ratios using net costs and HALYs gained (both discounted at 3%) were used to assess cost-effectiveness. Results Over the first 10 years, a mandatory iTFA limit (assumed to eliminate iTFA intake) was estimated to prevent 9996 (95% uncertainty interval: 8870 to 11 118) IHD deaths and 66 569 (58 862 to 74 083) IHD events, and to save US$90 million (78 to 102) in healthcare costs. The corresponding lifetime estimates were 259 934 (228 736 to 290 191), 479 308 (95% UI 420 472 to 538 177) and 518 (450 to 587). Policy implementation costs were estimated at US$17 million (11 to 23) over the first 10 years, and US$26 million USD (19 to 33) over the population’s lifetime. The intervention was estimated to be cost-saving, and findings were robust across several deterministic sensitivity analyses. Conclusion Our findings support mandating a limit of iTFAs as a cost-saving strategy to reduce the IHD burden in Nigeria

Biology · Business · Cost–benefit analysis · Environmental health · Coconut Research and Applications · Consumer Attitudes and Food Labeling · Fatty Acid Research and Health · Medicine

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