Prevalence and Molecular Epidemiology of Transmitted Drug Resistance and Genetic Transmission Networks Among Newly Diagnosed People Living With HIV/Aids in a Minority Area, China

Bibliographic Data

ID22067147
AuthorsDan Yuan (0000-0002-9074-8770, Sichuan Center for Disease Control and Prevention), Bin Yu (0000-0001-6980-7345, Sichuan University), Yiping Li (0000-0001-9942-2534, Sichuan Center for Disease Control and Prevention), Zixin Wang (0000-0002-8594-3803), Johnson Zixin Wang (0000-0002-1158-2304, Chinese University of Hong Kong), Meijing Liu (0000-0002-9785-8614, Sichuan University), Li Ye (0000-0003-0401-5691, Sichuan Center for Disease Control and Prevention), Yuling Huang (0000-0002-2879-6931, Sichuan Center for Disease Control and Prevention), Ling Su (0000-0002-6229-5137, Sichuan Center for Disease Control and Prevention), Yan Zhang (0000-0001-8460-2671, Sichuan Center for Disease Control and Prevention), Laze Api (Chinese Center For Disease Control and Prevention), Maogang Chen, Chang Zhou (0009-0001-0260-4268, Sichuan Center for Disease Control and Prevention), Li Liu (0000-0002-5257-3391, Sichuan Center for Disease Control and Prevention), Linglin Zhang (0000-0002-5003-5864, Sichuan Center for Disease Control and Prevention), Shu Liang (0000-0002-0331-246X, Sichuan Center for Disease Control and Prevention, corresponding author), Peng Jia (0000-0003-0110-3637, Wuhan University, corresponding author), Shujuan Yang (0009-0005-9168-3058, Sichuan University, corresponding author)
Year2021
Volume9
Pages731280-731280
Publication date2021-10-11
Peer ReviewedYes
Open AccessYes
TypeARTICLE
VenueFrontiers in Public Health (JOURNAL)
Journal identifiersISSN: 2296-2565 • E-ISSN: 2296-2565
PublisherFrontiers Media SA (PUBLISHER • CH)
DOI10.3389/fpubh.2021.731280
PMID34708015
OpenAlexW3207867092
LanguageEN
Citations received2
References cited39

Introduction: Transmitted drug resistance (TDR) can compromise antiretroviral therapy (ART) efficacy. We aimed to understand the molecular epidemiology of TDR and its genetic transmission networks among newly diagnosed people living with HIV/AIDS (PLWH). Methods: A total of 1,318 newly diagnosed PLWH, identified in all population-based HIV screening in an HIV-affected county of a minority area of China (i.e., Butuo county), were enrolled between January 1, 2018, and November 31, 2018. HIV-1 pol gene sequences were used for phylogenetic and genotypic drug resistance analyses. The genetic transmission networks were identified. Results: The prevalence of TDR among newly diagnosed PLWH was 8.12% (107/1,318). Patients in the stage of AIDS (adjusted odds ratio, OR: 2.32) and who had a history of sharing a needle ≥5 times (adjusted OR: 3.89) were more likely to have an increased risk of TDR. The prevalence of TDR for non-nucleoside reverse transcriptase inhibitors (NNRTIs) is higher than that of other inhibitors, with a relatively high prevalence of three mutations [V179D/E/DE (4.93%), K103N/KN (3.11%), and E138A/G (1.52%)]. A total of 577 (43.78%) pol sequences were involved in the genetic transmission network, with 171 clusters ranging in size from 2 to 91 pol sequences; 37.38% (40/107) of individuals carrying TDR were involved in the network, and individuals with the same TDR-associated mutations were usually cross-linked. Conclusions: Our data suggest a relatively high level of TDR and many transmission clusters among the newly diagnosed PLWH. Targeted intervention, early identification, and monitoring of resistance are warranted to reduce the TDR and prevent HIV-1 transmission in areas with a high rate of HIV-1

Biology · Drug resistance · Environmental health · Gene · Genetic epidemiology · Genotype · Molecular epidemiology · Odds ratio · Population · Sexual transmission · Demography · HIV Research and Treatment · HIV/AIDS drug development and treatment · HIV/AIDS Research and Interventions · Medicine · Epidemiology · Genetics · Internal Medicine · Virology

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