Transmission of Mycobacterium tuberculosis in schools
A molecular epidemiological study using whole-genome sequencing in Guangzhou, China
Bibliographic Data
| ID | 22068059 |
|---|---|
| Authors | Ying Lin (0000-0003-4979-940X, Guangzhou Chest Hospital), Yuhua Du (0009-0006-6276-6062, Guangzhou Chest Hospital), Hongcheng Shen (0000-0001-6588-4714, Guangzhou Chest Hospital), Yangfeng Guo (Guangzhou Center for Disease Control and Prevention), Ting Wang (0000-0003-3792-1260, Guangzhou Chest Hospital), Keng Lai (Guangzhou Chest Hospital), Danni Zhang (0009-0006-4697-2691, Guangzhou Medical University), Guangmin Zheng (0009-0001-7448-5114, Guangzhou Medical University), Guifeng Wu (0000-0001-6274-3123, Guangzhou Chest Hospital), Lei Yu (0000-0001-7883-197X, Guangzhou Chest Hospital), Jianxiong Liu (0009-0003-2367-645X, State Key Laboratory of Respiratory Disease, corresponding author) |
| Year | 2023 |
| Volume | 11 |
| Pages | 1156930-1156930 |
| Publication date | 2023-05-11 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Frontiers in Public Health (JOURNAL) |
| Journal identifiers | ISSN: 2296-2565 • E-ISSN: 2296-2565 |
| Publisher | Frontiers Media SA (PUBLISHER • CH) |
| DOI | 10.3389/fpubh.2023.1156930 |
| PMID | 37250072 |
| OpenAlex | W4376279402 |
| Language | EN |
| Citations received | 1 |
| References cited | 21 |
Background: China is a country with a high burden of tuberculosis (TB). TB outbreaks are frequent in schools. Thus, understanding the transmission patterns is crucial for controlling TB. Method: strains isolated from patients with TB attending schools during 2015 to 2019 in Guangzhou, China. Result: The TB incidence was mainly concentrated in regular secondary schools and technical and vocational schools. The incidence of drug resistance among the students was 16.30% (22/135). The phylogenetic tree showed that 79.26% (107/135) and 20.74% (28/135) of the strains belonged to lineage 2 (Beijing genotype) and lineage 4 (Euro-American genotype), respectively. Among the 135 isolates, five clusters with genomic distance within 12 single nucleotide polymorphisms were identified; these clusters included 10 strains, accounting for an overall clustering rate of 7.4% (10/135), which showed a much lower transmission index. The distance between the home or school address and the interval time of symptom onset or diagnosis indicated that campus dissemination and community dissemination may be existed both, and community dissemination is the main. Conclusion and recommendation: TB cases in Guangzhou schools were mainly disseminated and predominantly originated from community transmission. Accordingly, surveillance needs to be strengthened to stop the spread of TB in schools
Biology · Environmental health · Gene · Genotype · Molecular epidemiology · Mycobacterium tuberculosis · Outbreak · Pathology · Tuberculosis · Veterinary medicine · Diagnosis and treatment of tuberculosis · Medicine · Mycobacterium research and diagnosis · Tuberculosis Research and Epidemiology · Epidemiology · Genetics · Internal Medicine · Virology
| Unique citing works | 1 |
|---|---|
| Citations per year | 0.5 |
| Citation span | 2024 - 2024 (1) |
| Citation velocity | recent |
| Highly cited | No |
| Citation types | Neutral: 1 |