Optical spectral diagnostics of the oxygenation level in periodontal tissues and photodynamic therapy using methylene blue in children with cerebral palsy
Bibliographic Data
| ID | 22068228 |
|---|---|
| Authors | Н С Морозова (0000-0002-6453-1615, Sechenov University, corresponding author), Natalia S MOROZOVA, Iuliia A Kozlitina (Sechenov University), Vladimir I Makarov (0000-0003-1813-1837), Vladimir Makarov (0000-0002-4423-5042, Prokhorov General Physics Institute), Victor B Loschenov (0000-0002-0507-2367, Prokhorov General Physics Institute), Vasiliy M Grinin (Sechenov University), S Yu Ivanov (0000-0001-5458-0192, Peoples' Friendship University of Russia), Maria S Kashtanova (Sechenov University) |
| Year | 2023 |
| Volume | 11 |
| Pages | 961066-961066 |
| Publication date | 2023-01-30 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Frontiers in Public Health (JOURNAL) |
| Journal identifiers | ISSN: 2296-2565 • E-ISSN: 2296-2565 |
| Publisher | Frontiers Media SA (PUBLISHER • CH) |
| DOI | 10.3389/fpubh.2023.961066 |
| PMID | 36794072 |
| OpenAlex | W4318457191 |
| Language | EN |
| References cited | 67 |
Dental diseases occur in children with cerebral palsy three times higher than in healthy children. Low values of the unstimulated salivation rate (<0.3 ml per minute), pH and buffer capacity, changes in enzyme activity and sialic acid concentration, as well as increased saliva osmolarity and total protein concentration, which indicates impaired hydration, are the factors in the development of a gingiva disease in case of cerebral palsy. This leads to increased bacterial agglutination and the formation of acquired pellicle and biofilm, leading to the formation of dental plaque. There is a tendency toward an increase in the concentration of hemoglobin and a decrease in the degree of hemoglobin oxygenation, as well as an increase in the generation of reactive oxygen and nitrogen species. Photodynamic therapy (PDT) with the use of photosensitizer methylene blue improves blood circulation and the degree of oxygenation in periodontal tissues, as well as eliminates a bacterial biofilm. Analysis of back diffuse reflection spectra makes it possible to conduct non-invasive monitoring determine tissue areas with a low level of hemoglobin oxygenation for precision photodynamic exposure
Anesthesia · Cerebral palsy · Gingivitis · Hemoglobin · Methylene blue · Oxygenation · Photodynamic therapy · Chemistry · Dentistry · Laser Applications in Dentistry and Medicine · Medicine · Optical Imaging and Spectroscopy Techniques · Photodynamic Therapy Research Studies · Biochemistry · Internal Medicine
| Highly cited | No |
|---|