Cost-effectiveness of various immunization schedules with inactivated Sabin strain polio vaccine in Hangzhou, China

Bibliographic Data

ID22069176
AuthorsYuyang Xu (0000-0002-3962-3526, Hangzhou Center for Disease Control and Prevention), Yan Liu (0000-0002-1612-779X, Hangzhou Center for Disease Control and Prevention, corresponding author), Jun Wang (0000-0003-4485-7201, Hangzhou Center for Disease Control and Prevention), Xinren Che (Hangzhou Center for Disease Control and Prevention), Jian Du (0000-0001-8436-778X, Hangzhou Center for Disease Control and Prevention), Xiaoping Zhang (0000-0003-0995-4989, Hangzhou Center for Disease Control and Prevention), Wenwen Gu (0000-0003-4430-6223, Hangzhou Center for Disease Control and Prevention), Xuechao Zhang (0009-0006-9042-2478, Hangzhou Center for Disease Control and Prevention), Wei Jiang (0000-0002-0811-0648, Hangzhou Center for Disease Control and Prevention)
Year2022
Volume10
Pages990042-990042
Publication date2022-09-23
Open AccessYes
TypeARTICLE
VenueFrontiers in Public Health (JOURNAL)
Journal identifiersISSN: 2296-2565 • E-ISSN: 2296-2565
PublisherFrontiers Media SA (PUBLISHER • CH)
DOI10.3389/fpubh.2022.990042
PMID36211670
OpenAlexW4296828489
LanguageEN
Citations received1
References cited35

Background It is necessary to select suitable inactivated poliovirus vaccine(IPV) and live, attenuated oral poliovirus vaccine (OPV) sequential immunization programs and configure the corresponding health resources. An economic evaluation was conducted on the sequential procedures of Sabin strain-based IPV (sIPV) and bivalent OPV (bOPV) with different doses to verify whether a cost-effectiveness target can be achieved. This study aimed to evaluate the cost-effectiveness of different sIPV immunization schedules, which would provide convincing evidence to further change the poliovirus vaccine (PV) immunization strategies in China. Methods Five strategies were included in this analysis. Based on Strategy 0(S 0 ), the incremental cost (IC), incremental effect (IE), and incremental cost-effectiveness ratio (ICER) of the four different strategies (S 1 /S 2 /S 3 /S 4 ) were calculated based on the perspective of the society. Seven cost items were included in this study. Results of field investigations and expert consultations were used to calculate these costs. Results The ICs of S 1 /S 2 /S 3 /S 4 was Chinese Yuan (CNY) 30.77, 68.58, 103.82, and 219.82 million, respectively. The IE of vaccine-associated paralytic poliomyelitis (IE VAPP ) cases of S 1 /S 2 /S 3 /S 4 were 0.22, 0.22, 0.22, and 0.11, respectively, while the IE of disability-adjusted life-years (IE DALY ) of S 1 /S 2 /S 3 /S 4 were 8.98, 8.98, 8.98, and 4.49, respectively. The ICER VAPP of S 1 /S 2 /S 3 /S 4 gradually increased to CNY 13.99, 31.17, 47.19, and 199.83 million/VAPP, respectively. The ICER DALY of S 1 /S 2 /S 3 /S 4 also gradually increased to CNY 0.34, 0.76, 1.16, and 4.90 million/DALY, respectively. Conclusion ICER VAPP and ICER DALY were substantially higher for S 3 (four-sIPV) and S 4 (replacement of self-funded sIPV based on one-sIPV-three-bOPV). Two-sIPV-two-bOPV had a cost-effectiveness advantage, whereas S2/S3/S4 had no cost-effectiveness advantage

Antibody · China · Cost effectiveness · Cost-effectiveness analysis · Immunization · Inactivated Poliovirus Vaccine · Poliomyelitis · Poliomyelitis eradication · Poliovirus · Routine immunization · Vaccination · Virus · Medicine · Respiratory viral infections research · Viral gastroenteritis research and epidemiology · Viral Infections and Immunology Research · Immunology · Virology

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