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Sex difference in the associations among obesity-related indices with incidence of diabetes mellitus in a large Taiwanese population follow-up study

Bibliographic Data

ID22069294
AuthorsTung‐Ling Chung (0009-0002-9060-6331, Kaohsiung Medical University), Tung-Ling Chung, Yi‐Hsueh Liu (0000-0001-6915-3679, Kaohsiung Medical University), Yi-Hsueh Liu, Pei-Yu Wu (0000-0002-5553-1496, Kaohsiung Medical University), Jiun‐Chi Huang (0000-0002-5897-2860, Kaohsiung Medical University), Jiun-Chi Huang, Szu‐Chia Chen (0000-0002-1610-4184, Kaohsiung Medical University, corresponding author), Szu-Chia Chen (0009-0001-7989-6297)
Year2023
Volume11
Pages1094471-1094471
Publication date2023-01-20
Open AccessYes
TypeARTICLE
VenueFrontiers in Public Health (JOURNAL)
Journal identifiersISSN: 2296-2565 • E-ISSN: 2296-2565
PublisherFrontiers Media SA (PUBLISHER • CH)
DOI10.3389/fpubh.2023.1094471
PMID36741951
OpenAlexW4317519902
LanguageEN
References cited53

Background: Obesity is a major risk factor for diabetes mellitus (DM), which is in turn a major risk factor for cardiovascular diseases such as coronary artery disease and stroke. As few studies have investigated sex differences in the association between obesity and incidence of DM, the aim of this longitudinal study was to explore this issue in a large group of Taiwanese participants. Methods: A total of 24,346 participants were enrolled in this study, of whom 8,334 (mean age, 50.6 ± 11.0 years) were male and 16,012 (mean age, 50.5 ± 10.1 years) were female. The following obesity-related indices were studied: body mass index, waist-to-height ratio, waist-to-hip ratio (WHR), body roundness index, conicity index (CI), body adiposity index, abdominal volume index, lipid accumulation product (LAP), and visceral adiposity index (VAI). Results: < 0.001). In the male participants, the strongest predictors for incidence of DM were LAP (AUC = 0.692), WHtR (AUC = 0.684), and WHR (AUC = 0.683). In the female participants, the strongest predictors were LAP (AUC = 0.744), WHtR (AUC = 0.710) and VAI (AUC = 0.710), followed by BRI (AUC = 0.708). Conclusion: Strong associations were found between the studied obesity-related indices and incidence of DM, and sex differences were found. Hence, to better control DM, reducing body weight may be beneficial in addition to lifestyle modifications, diet control, and pharmacological interventions

Body mass index · Diabetes mellitus · Environmental health · Obesity · Population · Bariatric Surgery and Outcomes · Cardiovascular Disease and Adiposity · Demography · Diabetes, Cardiovascular Risks, and Lipoproteins · Medicine · Endocrinology · Gerontology · Internal Medicine

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