High expression of protein tyrosine phosphatase receptor S (PTPRS) is an independent prognostic marker for cholangiocarcinoma
Bibliographic Data
| ID | 22069908 |
|---|---|
| Authors | Muntinee Lertpanprom (Khon Kaen University), Atit Silsirivanit (0000-0002-5777-3843, Khon Kaen University), Patcharaporn Tippayawat (0000-0002-4452-1284, Khon Kaen University), Tanakorn Proungvitaya (Khon Kaen University), Sittiruk Roytrakul (0000-0003-3696-8390, National Science and Technology Development Agency), Siriporn Proungvitaya (0000-0002-2170-4934, Khon Kaen University, corresponding author) |
| Year | 2022 |
| Volume | 10 |
| Pages | 835914-835914 |
| Publication date | 2022-08-01 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Frontiers in Public Health (JOURNAL) |
| Journal identifiers | ISSN: 2296-2565 • E-ISSN: 2296-2565 |
| Publisher | Frontiers Media SA (PUBLISHER • CH) |
| DOI | 10.3389/fpubh.2022.835914 |
| PMID | 35991009 |
| OpenAlex | W4289444116 |
| Language | EN |
| References cited | 49 |
Cholangiocarcinoma (CCA) is an aggressive tumor of the bile duct with a high rate of mortality. Lymph node metastasis is an important factor facilitating the progression of CCA. A reliable biomarker for diagnosis, progression status, or prognosis of CCA is still lacking. To identify a novel and reliable biomarker for diagnosis/prognosis of CCA, liquid chromatography-mass spectrometry and tandem mass spectrometry (LC-MS/MS) in combination with bioinformatics analysis were applied for the representative serum samples of patients with CCA. The proteome results showed that protein tyrosine phosphatase receptor S (PTPRS) had the highest potential candidate. Then, a dot blot assay was used to measure the level of serum PTPRS in patients with CCA ( n = 80), benign biliary disease patients (BBD; n = 39), and healthy controls (HC; n = 55). PTPRS level of CCA sera (14.38 ± 9.42 ng/ml) was significantly higher than that of BBD (10.7 ± 5.05 ng/ml) or HC (6 ± 3.73 ng/ml) ( P < 0.0001). PTPRS was associated with serum albumin ( P = 0.028), lymph node metastasis ( P = 0.038), and the survival time of patients ( P = 0.011). Using a log-rank test, higher serum PTPRS level was significantly ( P = 0.031) correlated with a longer overall survival time of patients with CCA, and PTPRS was an independent prognostic marker for CCA superior to carbohydrate antigen 19-9 (CA19-9), carcinoembryonic antigen (CEA) or alkaline phosphatase (ALP). High expression of PTPRS could be a good independent prognostic marker for CCA
Biology · Gene · Pathology · Phosphatase · Phosphorylation · Protein expression · Protein phosphatase 2 · Protein tyrosine phosphatase · Receptor · Receptor tyrosine kinase · Cholangiocarcinoma and Gallbladder Cancer Studies · Medicine · MicroRNA in disease regulation · RNA modifications and cancer · Cancer Research · Genetics · Internal Medicine · Oncology
| Highly cited | No |
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