Association Between Functional Limitations and Incident Cardiovascular Diseases and All-Cause Mortality Among the Middle-Aged and Older Adults in China
A Population-Based Prospective Cohort Study
Bibliographic Data
| ID | 22070057 |
|---|---|
| Authors | Zhao Hu (0000-0002-6787-4074, Central South University), Baohua Zheng (0009-0008-7610-5913, Central South University), Atipatsa Chiwanda Kaminga (0000-0002-6556-4590, Central South University), Feixiang Zhou (0000-0003-4939-9393, Central South University), Huilan Xu (0000-0002-9488-8121, Central South University, corresponding author) |
| Year | 2022 |
| Volume | 10 |
| Pages | 751985-751985 |
| Publication date | 2022-02-11 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Frontiers in Public Health (JOURNAL) |
| Journal identifiers | ISSN: 2296-2565 • E-ISSN: 2296-2565 |
| Publisher | Frontiers Media SA (PUBLISHER • CH) |
| DOI | 10.3389/fpubh.2022.751985 |
| PMID | 35223720 |
| OpenAlex | W4211185110 |
| Language | EN |
| Citations received | 6 |
| References cited | 61 |
BACKGROUND: The prevalence of functional limitations is relatively high among the middle-aged and older adults. However, the contribution of functional limitations to subsequent incident cardiovascular diseases (CVD) and death is unclear. This study aims to examine the association between functional limitations and incident CVD and all-cause mortality among the middle-aged and older adults. METHODS: This is a nationally representative prospective cohort study. Participants were middle-aged and older Chinese adults from The China Health and Retirement Longitudinal Study. Functional limitations were measured using activities of daily living (ADL) scale and instrumental activities of daily living (IADL) scale. Incident CVD and death were recorded at followed-up from June 1, 2011, up until August 31, 2018. Cox proportional hazards model was used to assess the association between functional limitations and incident CVD and all-cause mortality. RESULTS: A total of 11,013 participants were included in this study. During the 7 years of follow-up, 1,914 incident CVD and 1,182 incident deaths were identified. Participants with functional limitations were associated with a 23% increased risk of incident CVD (HR, 1.23, 95% CI:1.08,1.39) after adjusting for age, gender, residential area, marital status, education, smoking, alcohol drinking, sleep duration, nap duration, depression symptoms, social participation, history of hypertension, diabetes, dyslipidemia, use of hypertension medications, diabetes medications, and lipid-lowering therapy. Moreover, participants with functional limitations were associated with a 63% increased risk of all-cause mortality (HR,1.63, 95%CI: 1.41,1.89) after adjusting for potential confounders. CONCLUSIONS: Functional limitations were significantly associated with subsequent incident CVD and death among the middle-aged and older Chinese adults
Activities of daily living · Cohort · Cohort study · Confounding · Diabetes mellitus · Disease · Dyslipidemia · Environmental health · Marital status · Physical therapy · Population · Proportional hazards model · Prospective cohort study · Chronic Disease Management Strategies · Demography · Frailty in Older Adults · Health disparities and outcomes · Medicine · Gerontology · Internal Medicine
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| Unique citing works | 6 |
|---|---|
| Citations per year | 1,5 |
| Citation span | 2022 - 2025 (4) |
| Citation velocity | recent |
| Highly cited | No |
| Citation types | Neutral: 5 |