Epidemiology and genotypes analysis of human papillomavirus infection in Huizhou, China

Bibliographic Data

ID22070458
AuthorsZhun Shu (Huizhou Central People's Hospital), Wenli Zhao (0000-0001-6152-1692, Huizhou Central People's Hospital), Xuebing Zhan (Huizhou Central People's Hospital), Jiaqi Zeng (0009-0002-1738-8948, Jinan University, corresponding author), Jingyi Li (0009-0008-6009-6055, Huizhou Central People's Hospital, corresponding author)
Year2024
Volume12
Pages1440480-1440480
Publication date2024-08-09
Peer ReviewedYes
Open AccessYes
TypeARTICLE
VenueFrontiers in Public Health (JOURNAL)
Journal identifiersISSN: 2296-2565 • E-ISSN: 2296-2565
PublisherFrontiers Media SA (PUBLISHER • CH)
DOI10.3389/fpubh.2024.1440480
PMID39185110
OpenAlexW4401470461
LanguageEN
Citations received1
References cited33

Background Human papillomavirus (HPV) is a main pathogenic factor for cervical carcinoma. The prevalence and genotypes distribution of HPV vary in different regions. Thus, our study aimed to investigate the epidemiology of HPV in Huizhou, China. Methods HPV tests were detected in 5,325 female outpatients, we focused on the overall HPV prevalence, genotypes distribution, and the correlation of HPV genotypes with cervical cytology. Results The overall HPV prevalence was 27.53%, HPV52, HPV58, HPV39, HPV16 and HPV51 were predominant genotypes with single infection rate of 70.80%. HPV infection rate showed a U-shaped age distribution, statistical differences were observed among 5 age groups (χ 2 = 50.497, p < 0.01), and the higher positive rate was aged under 30 (34.42%) and above 60 (34.74%). Among high-risk HPV (hrHPV) infections, 60.69% involved NILM, 0.99% HSIL. The degrees of cervical lesions in multiple hrHPV infections were worse than those in single infection ( p < 0.01). Conclusion The HPV infection rate is high in Huizhou, Guangdong, single infection was predominant. HPV infection presented with a U-shaped age distribution. Multiple hrHPV infection was worrying since it may aggravate cervical lesions. Women should pay more attention to HPV detection and choose a more appropriate HPV vaccine according to local HPV type distribution

Biology · Cancer · Cervical cancer · Cervical carcinoma · Gene · Genotype · Gynecology · HPV infection · Human papillomavirus · Infection rate · Cervical Cancer and HPV Research · Genital Health and Disease · Medicine · Reproductive tract infections research · Epidemiology · Genetics · Internal Medicine · Surgery · Virology

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