The Diagnostic Value of Mitochondrial Mass of Peripheral T Lymphocytes in Early Sepsis
Bibliographic Data
| ID | 22070540 |
|---|---|
| Authors | Ling-Xiao Pang, Lingxiao Pang (Zhejiang Provincial People's Hospital), Wenwei Cai (Zhejiang Provincial People's Hospital), Wen-Wei Cai, Lue Chen (0000-0001-7658-5787, Zhejiang Provincial People's Hospital), Jin Fu (0000-0002-4792-8813), Fu Jin (0000-0002-7020-7993, Bengbu Medical College), Chun-Xiao Xia (Zhejiang Chinese Medical University), Jiayan Li (0000-0002-8521-2461, Zhejiang Chinese Medical University), Jia-Yan Li, Qian Li (0000-0003-1286-8539, Zhejiang Provincial People's Hospital, corresponding author) |
| Year | 2022 |
| Volume | 10 |
| Pages | 928306-928306 |
| Publication date | 2022-07-14 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Frontiers in Public Health (JOURNAL) |
| Journal identifiers | ISSN: 2296-2565 • E-ISSN: 2296-2565 |
| Publisher | Frontiers Media SA (PUBLISHER • CH) |
| DOI | 10.3389/fpubh.2022.928306 |
| PMID | 35910903 |
| OpenAlex | W4285388491 |
| Language | EN |
| References cited | 38 |
Background Studies have shown that lymphocyte dysfunction can occur during the early stages of sepsis and that cell dysfunction is associated with mitochondrial dysfunction. Therefore, quantifying the mitochondrial function of lymphocytes in patients with sepsis could be valuable for the early diagnosis of sepsis. Methods Seventy-nine patients hospitalized from September 2020 to September 2021 with Sepsis-3 were retrospectively analyzed and subsequently compared with those without sepsis. Results Univariate analysis showed statistical differences between the data of the two groups regarding age, neutrophil/lymphocyte, procalcitonin (PCT), C-reactive protein, total bilirubin, serum creatinine, type B natriuretic peptide, albumin, prothrombin time, activated partial thromboplastin time, lactic acid, single-cell mitochondrial mass (SCMM)-CD3, SCMM-CD4, SCMM-CD8, and Acute Physiology and Chronic Health Evaluation II score ( P < 0.05). Multivariate logistic regression analysis performed on the indicators mentioned above demonstrated a statistical difference in PCT, lactic acid, SCMM-CD4, and SCMM-CD8 levels between the two groups ( P < 0.05). The receiver operating characteristic curves of five models were subsequently compared [area under the curve: 0.740 (PCT) vs. 0.933 (SCMM-CD4) vs. 0.881 (SCMM-CD8) vs. 0.961 (PCT + SCMM-CD4) vs. 0.915 (PCT+SCMM-CD8), P < 0.001]. Conclusion SCMM-CD4 was shown to be a better diagnostic biomarker of early sepsis when compared with the traditional biomarker, PCT. Furthermore, the value of the combination of PCT and SCMM-CD4 in the diagnosis of early sepsis was better than that of SCMM-CD4 alone
Biology · Biomarker · CD8 · Creatinine · Immune system · Lymphocyte · Multivariate analysis · Procalcitonin · Receiver operating characteristic · Sepsis · Univariate analysis · Immune Response and Inflammation · Inflammation biomarkers and pathways · Medicine · Sepsis Diagnosis and Treatment · Gastroenterology · Immunology · Internal Medicine
| Highly cited | No |
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