Long-term vaccine efficacy of a 2-dose varicella vaccine in China from 2011 to 2021
A retrospective observational study
Bibliographic Data
| ID | 22071088 |
|---|---|
| Authors | Mingming Shu, Dandan Zhang (0000-0003-3443-9946, Ningbo Center for Disease Control and Prevention), Rui Ma (0000-0002-3367-674X, Ningbo Center for Disease Control and Prevention), Tianchi Yang (0000-0002-9971-5107, Ningbo Center for Disease Control and Prevention), Xingqiang Pan (Ningbo Center for Disease Control and Prevention, corresponding author) |
| Year | 2022 |
| Volume | 10 |
| Pages | 1039537-1039537 |
| Publication date | 2022-11-08 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Frontiers in Public Health (JOURNAL) |
| Journal identifiers | ISSN: 2296-2565 • E-ISSN: 2296-2565 |
| Publisher | Frontiers Media SA (PUBLISHER • CH) |
| DOI | 10.3389/fpubh.2022.1039537 |
| PMID | 36424959 |
| OpenAlex | W4308590017 |
| Language | EN |
| Citations received | 1 |
| References cited | 39 |
Objective: A 2-dose varicella vaccine immunization strategy has been implemented in many cities in China, but there is few evidence on a long-term evaluation of the efficacy of the 2-dose varicella vaccine from China. This study aims to assess the long-term vaccine efficacy of the two doses varicella vaccine and analysis of its influencing factors. Methods: A retrospective study was carried out in 837,144 children born between 2011 and 2017 in Ningbo, Easten China. The logistic regression was performed to estimate varicella vaccine effectiveness (VE). Results: The overall VE of 2 doses of varicella vaccine compared without the vaccine was 90.31% (89.24-91.26%), and the overall incremental VE of 2 doses of varicella vaccine compared to the 1-dose was 64.71% (59.92-68.93%). Moreover, the varicella vaccination age of the second dose and the interval between 2 doses were both associated with VE. The VE compared to that without the vaccine in children vaccinated at <4 years old was 91.22% (95%CI: 90.16-92.17%) which was higher than in children vaccinated at ≥4 years old (VE: 86.79%; 95%CI: 84.52-88.73). And the effectiveness of the vaccine was 93.60% (95%CI: 92.19-94.75%) in children with the interval of the 2 doses ≤ 24 months significantly higher than in children with the interval of ≥36 months (VE: 85.62%, 95%CI: 82.89-87.91%). Conclusions: This study provides evidence for long-term VE of the 2-dose varicella vaccine and the better age for 2-dose vaccination and the interval between 2 doses of the vaccine in China
Chickenpox Vaccine · China · Immune system · Immunization · Observational study · Political science · Retrospective cohort study · Varicella vaccine · Herpesvirus Infections and Treatments · Medicine · Poxvirus research and outbreaks · Sperm and Testicular Function · Immunology · Internal Medicine · Pediatrics · Virology
| Unique citing works | 1 |
|---|---|
| Citations per year | 1 |
| Citation span | 2025 - 2025 (1) |
| Citation velocity | recent |
| Highly cited | No |
| Citation types | Neutral: 1 |