Correlation of bisphenol A and bisphenol S exposure with the metabolic parameters on FDG PET/CT image
Bibliographic Data
| ID | 22072192 |
|---|---|
| Authors | Liu Xiao (0000-0003-0252-1566, Sichuan University), Wen Xue (0000-0003-0769-3121, Sichuan University), Xue Wen (0000-0002-8503-5960), Lin Li (0000-0003-2896-7988, Sichuan University), Yuhao Li (0000-0002-8086-0881, Sichuan University, corresponding author) |
| Year | 2024 |
| Volume | 12 |
| Pages | 1433122-1433122 |
| Publication date | 2024-11-27 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Frontiers in Public Health (JOURNAL) |
| Journal identifiers | ISSN: 2296-2565 • E-ISSN: 2296-2565 |
| Publisher | Frontiers Media SA (PUBLISHER • CH) |
| DOI | 10.3389/fpubh.2024.1433122 |
| PMID | 39664558 |
| OpenAlex | W4404774393 |
| Language | EN |
| References cited | 20 |
Purpose Bisphenol A (BPA) and its analogs have been proved to be harmful to human health. This study aimed to assess the correlation of BPA and its major analog, Bisphenol S (BPS), with metabolic parameters within main organs using 18 F-fluorodeoxyglucose positron emission tomography/computed tomography ( 18 F-FDG PET/CT) imaging. Methods A retrospective analysis was conducted on patients who had undergone FDG PET/CT imaging and were also examined for BPA and BPS levels. Urine samples were collected for detection of BPA and BPS. Standardized uptake values (SUV max and SUV mean ) of main organ tissues including liver, blood, spleen, muscle, thyroid, and cerebral cortex were quantified. Statistical analysis was performed using Spearman’s rank correlation. Results Forty patients (20 female, 20 male; mean age: 56.1 ± 15.4 years) were included. Mean urine BPA and BPS concentrations were 2.1 ± 1.2 ng/mL and 1 ± 0.6 ng/mL, respectively. Urine BPA exhibited a moderate positive correlation with liver SUV max ( r = 0.351, p = 0.026) and SUV mean ( r = 0.361, p = 0.022) in male. No significant correlations were found between BPA and blood, muscle, spleen, thyroid, and cerebral cortex ( p > 0.05). Conversely, urine BPS demonstrated a negative correlation with thyroid SUV max in male ( r = −0.43, p = 0.012) and SUV mean ( r = −0.432, p = 0.012), while a positive correlation was observed between BPS and cerebral cortex SUV max in female ( r = 0.366, p = 0.033). Conclusion Urinary levels of BPA and BPS exerted distinct influences on tissue metabolic parameters observed via FDG PET/CT imaging, particularly affecting the liver, thyroid, and cerebral cortex
Bisphenol · Bisphenol A · Correlation · Nuclear medicine · Positron emission tomography · Radiology · Effects and risks of endocrine disrupting chemicals · Materials Science · Mathematics · Medicine · Microplastics and Plastic Pollution
| Citation velocity | historical |
|---|---|
| Highly cited | No |