Point-of-Care Diagnostic Tools for Surveillance of Sars-CoV-2 Infections

Bibliographic Data

ID22072508
AuthorsDhanasekaran Sakthivel (0000-0003-2894-2545), David Delgado-Diaz, David Jose Delgado-Diaz (0000-0001-5982-7641), Laura McArthur (Monash University), William Hopper, Jack S Richards (0000-0001-5786-6989, Burnet Institute), Charles A Narh (0000-0002-2018-5634, Burnet Institute, corresponding author)
Year2021
Volume9
Pages766871-766871
Publication date2021-11-25
Open AccessYes
TypeARTICLE
VenueFrontiers in Public Health (JOURNAL)
Journal identifiersISSN: 2296-2565 • E-ISSN: 2296-2565
PublisherFrontiers Media SA (PUBLISHER • CH)
DOI10.3389/fpubh.2021.766871
PMID34900912
OpenAlexW3216969496
LanguageEN
References cited109

Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is a recently emerged and highly contagious virus that causes coronavirus disease 2019 (COVID-19). As of August 24, 2021, there were more than 212 million confirmed COVID-19 cases and nearly 4.4 million deaths reported globally. Early diagnosis and isolation of infected individuals remains one of the most effective public health interventions to control SARS-CoV-2 spread and for effective clinical management of COVID-19 cases. Currently, SARS-CoV-2 infection is diagnosed presumptively based on clinical symptoms and confirmed by detecting the viral RNA in respiratory samples using reverse transcription polymerase chain reaction (RT-PCR). Standard RT-PCR protocols are time consuming, expensive, and technically demanding, which makes them a poor choice for large scale and point-of-care screening in resource-poor settings. Recently developed isothermal nucleic acid amplification tests (iNAAT), antigen and/or serological tests are cost-effective to scale COVID-19 testing at the point-of-care (PoC) and for surveillance activities. This review discusses the development of rapid PoC molecular tools for the detection and surveillance of SARS-CoV-2 infections

Bioinformatics · Biology · Coronavirus · Disease · Infection control · Intensive care medicine · Pathology · Point of care · Point-of-care testing · Advanced biosensing and bioanalysis techniques · Biosensors and Analytical Detection · Medicine · SARS-CoV-2 detection and testing · Immunology · Internal Medicine · Virology

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