Exploring the microbial landscape
Uncovering the pathogens associated with community-acquired pneumonia in hospitalized patients
Bibliographic Data
| ID | 22072986 |
|---|---|
| Authors | Karin Hansen (0000-0001-9166-9452, Lund University), Linda Yamba Yamba (0009-0008-9369-975X, Lund University), Lisa Wasserstrom (0000-0002-5131-876X, Lund University), Elisabeth Rünow (Lund University), Tommy Göransson (Lund University), Anna Nilsson (0000-0001-5885-7101, Lund University), Jonas Ahl (0000-0003-1673-3885, Lund University), Kristian Riesbeck (0000-0001-6274-6965, Lund University, corresponding author) |
| Year | 2023 |
| Volume | 11 |
| Pages | 1258981-1258981 |
| Publication date | 2023-12-13 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Frontiers in Public Health (JOURNAL) |
| Journal identifiers | ISSN: 2296-2565 • E-ISSN: 2296-2565 |
| Publisher | Frontiers Media SA (PUBLISHER • CH) |
| DOI | 10.3389/fpubh.2023.1258981 |
| PMID | 38152664 |
| OpenAlex | W4389663926 |
| Language | EN |
| References cited | 30 |
Objectives This study aimed to investigate the etiology, clinical features, and outcomes of community-acquired pneumonia (CAP) in adults. Understanding the causative pathogens is essential for effective treatment and prevention. Design Between 2016–2018, 518 hospitalized adults with CAP and 241 controls without symptoms were prospectively enrolled. Urine samples were collected for pneumococcal urinary antigen tests and nasopharyngeal swabs for viral and bacterial analysis, combined with routine diagnostic care. Results Among the included CAP patients, Streptococcus pneumoniae was the most common pathogen, detected in 28% of patients, followed by Haemophilus influenzae in 16%. Viruses were identified in 28%, and concurrent viruses and bacteria were detected in 15%. There was no difference in mortality, length of stay, or symptoms at hospitalization when comparing patients with bacterial, viral, or mixed etiologies. Among the control subjects without respiratory symptoms, S. pneumoniae , H. influenzae , or Moraxella catarrhalis were detected in 5–7%, and viruses in 7%. Conclusion Streptococcus pneumoniae emerged as the predominant cause of CAP, followed closely by viruses and H. influenzae . Intriguingly, symptoms and outcome were similar regardless of etiology. These findings highlight the complexity of this respiratory infection and emphasize the importance of comprehensive diagnostic and treatment strategies. Clinical Trial Registration : ClinicalTrials.gov , identifier [NCT03606135]
Community-acquired pneumonia · Data science · Intensive care medicine · Pneumonia · Computer Science · Emergency and Acute Care Studies · Medicine · Pneumonia and Respiratory Infections · Respiratory viral infections research · Internal Medicine
Global burden of bacterial antimicrobial resistance in 2019
Estimates of the global, regional, and national morbidity, mortality, and aetiologies of lower respiratory infections in 195 countries, 1990–2016
Tobacco Product Use Among Adults — United States, 2019
Radiographically confirmed community-acquired pneumonia in hospitalized adults due to pneumococcal vaccine serotypes in Sweden, 2016–2018—The Ecaps study
| Highly cited | No |
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