Building a Population Representative Pediatric Biobank
Lessons Learned From the Greater Cincinnati Childhood Cohort
Bibliographic Data
| ID | 22073061 |
|---|---|
| Authors | Lisa J Martins (0000-0001-8702-9946, Cincinnati Children's Hospital Medical Center, corresponding author), Lisa J Martin, Liza Bronner Murrison (0000-0002-8668-3898, Cincinnati Children's Hospital Medical Center), Melinda Butsch Kovacic (0000-0001-6907-1446, Cincinnati Children's Hospital Medical Center) |
| Year | 2021 |
| Volume | 8 |
| Pages | 535116-535116 |
| Publication date | 2021-01-14 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Frontiers in Public Health (JOURNAL) |
| Journal identifiers | ISSN: 2296-2565 • E-ISSN: 2296-2565 |
| Publisher | Frontiers Media SA (PUBLISHER • CH) |
| DOI | 10.3389/fpubh.2020.535116 |
| PMID | 33520904 |
| OpenAlex | W3120531996 |
| Language | EN |
| Citations received | 1 |
| References cited | 99 |
Background: Biobanks can accelerate research by providing researchers with samples and data. However, hospital-based recruitment as a source for controls may create bias as who comes to the hospital may be different from the broader population. Methods: In an effort to broadly improve the quality of research studies and reduce costs and challenges associated with recruitment and sample collection, a group of diverse researchers at Cincinnati Children's Hospital Medical Center led an institution-supported initiative to create a population representative pediatric “Greater Cincinnati Childhood Cohort (GCC).” Participants completed a detailed survey, underwent a brief physician-led physical exam, and provided blood, urine, and hair samples. DNA underwent high-throughput genotyping. Results: In total, 1,020 children ages 3–18 years living in the 7 county Greater Cincinnati Metropolitan region were recruited. Racial composition of the cohort was 84% non-Hispanic white, 15% non-Hispanic black, and 2% other race or Hispanic. Participants exhibited marked demographic and disease burden differences by race. Overall, the cohort was broadly used resulting in publications, grants and patents; yet, it did not meet the needs of all potential researchers. Conclusions: Learning from both the strengths and weaknesses, we propose leveraging a community-based participatory research framework for future broad use biobanking efforts
Biobank · Biorepository · Cohort · Cohort study · Environmental health · Family medicine · Population · Childhood Cancer Survivors' Quality of Life · Ethics and Legal Issues in Pediatric Healthcare · Ethics in Clinical Research · Medicine · Gerontology
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| Citations per year | 0.25 |
|---|---|
| Citation span | 2022 - 2022 (1) |
| Highly cited | No |