A review of the clinical characteristics and management of immunosuppressed patients living with HIV or solid organ transplants infected with Sars-CoV-2 omicron variants
Bibliographic Data
| ID | 22073454 |
|---|---|
| Authors | Yan Song (0000-0002-8669-4116, Jilin University), Lixin Lou (Jilin University), Kaiyu Zhang (0009-0002-7178-0879, Jilin University, corresponding author) |
| Year | 2024 |
| Volume | 12 |
| Pages | 1327093-1327093 |
| Publication date | 2024-02-22 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Frontiers in Public Health (JOURNAL) |
| Journal identifiers | ISSN: 2296-2565 • E-ISSN: 2296-2565 |
| Publisher | Frontiers Media SA (PUBLISHER • CH) |
| DOI | 10.3389/fpubh.2024.1327093 |
| PMID | 38454994 |
| OpenAlex | W4392055432 |
| Language | EN |
| References cited | 83 |
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) omicron strain was first detected in South Africa in November 2021. Although clinical responses to SARS-CoV-2 depend on host immunity, it remains uncertain how immunosuppression affects subsequent coronavirus disease 2019-related (COVID-19-related) incidence, severity, and mortality, especially with respect to the omicron strain. Conversely, immunosuppressants are often thought to predispose to infection. To explore the associations between host immunity and infection with SARS-CoV-2 omicron variants, here we discuss two groups of immunosuppressed patients: organ transplant recipients, who generally receive exogenous immunosuppressants, and Human Immunodeficiency Virus (HIV)-infected patients, who often have disease-related immunosuppression. In summarizing the clinical features and prognoses of HIV-infected patients and human organ transplant recipients infected with SARS-CoV-2 omicron variants, we provide new insights into the pathogenesis of omicron SARS-CoV-2 and provide a framework for the management of these patients now and in the future
Disease · Immune system · Immunity · Immunosuppression · Pathogenesis · Pathology · COVID-19 Clinical Research Studies · Medicine · SARS-CoV-2 and COVID-19 Research · SARS-CoV-2 detection and testing · Immunology · Virology
| Highly cited | No |
|---|