Association between bisphenols A and the risk of endometriosis

Results from an updated meta-analysis

Bibliographic Data

ID22073667
AuthorsYue Chen (0000-0001-9582-590X, Wuhan University), Junle Wu (Anhui Medical University), Yuxin Wang (0000-0002-0305-9820, Anhui Medical University), Fang Wang (0000-0001-7353-9080, Kunming Medical University), Fuke Wang (Department of Critical Care Medicine, The Third Affiliated Hospital of Kunming Medical University), Qingxin Yang (0000-0002-7499-1332, Anhui Medical University), Yan Zhu (0000-0002-4955-2880, Shanghai University of Traditional Chinese Medicine), Qin Zhou (0000-0002-7192-3887, Shanghai University of Traditional Chinese Medicine), Chenyu Sun (0000-0003-3812-3164, Mayo Clinic Health System, corresponding author), Panpan Li (0000-0003-0114-5642, Shanghai University of Traditional Chinese Medicine, corresponding author)
Year2026
Volume14
Pages1817156-1817156
Publication date2026-05-04
Open AccessYes
TypeARTICLE
VenueFrontiers in Public Health (JOURNAL)
Journal identifiersISSN: 2296-2565 • E-ISSN: 2296-2565
PublisherFrontiers Media SA (PUBLISHER • CH)
DOI10.3389/fpubh.2026.1817156
PMID42158187
OpenAlexW7160098245
LanguageEN
References cited34

Background Recent studies have disputed the association between bisphenol A (BPA) and endometriosis. This updated meta-analysis was conducted to investigate the impact of BPA exposure on endometriosis. Methods This study evaluated BPA exposure and endometriosis risk, analyzing studies from Web of Science, PubMed, Embase, Cochrane Library, and Chinese databases (CNKI, CBM, Wanfang, VIP) through August 2025. Methodological quality was assessed via the Newcastle-Ottawa Scale (NOS) and the Agency for Healthcare Research and Quality Tool (AHRQ). Heterogeneity was quantified using I 2 statistics. Pooled odds ratios (ORs) and 95% CIs were calculated using fixed- or random-effects models according to heterogeneity. Subgroup analysis, sensitivity analysis, and publication bias assessment were supplemented to validate the overall finding. Results Seven studies comprising 2,488 participants were included in quantitative synthesis. The meta-analyses demonstrated that BPA exposure was associated with a statistically significant increase in endometriosis risk (OR = 1.36, 95% CI = 1.13–1.63, p = 0.008). Additionally, subgroup analysis indicated that BPA exposure may further elevate endometriosis risk in cases with different regions, populations, and measurement methods. Sensitivity analysis confirmed that the results of these meta-analyses were relatively robust. No publication bias was detected. Systematic review registration https://www.crd.york.ac.uk/PROSPERO/view/CRD420251019552 , identifier PROSPERO (CRD420251019552)

Endometriosis · MEDLINE · Meta-analysis · Odds ratio · Risk assessment · Subgroup analysis · Effects and risks of endocrine disrupting chemicals · Endometriosis Research and Treatment · Menopause: Health Impacts and Treatments

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