Exposure characteristics and cumulative risk assessment of bisphenol A and its substitutes
The Taiwan environmental survey for toxicants 2013
Bibliographic Data
| ID | 22075005 |
|---|---|
| Authors | Yu-Jung Lin (0000-0002-2507-3551, National Health Research Institutes), Hsin-Chang Chen, Hsin‐Chang Chen (0000-0003-4879-3639, Tunghai University), Jung-Wei Chang (0000-0002-3791-5349, National Yang Ming Chiao Tung University), Han-Bin Huang (0000-0002-6827-7087, National Defense Medical Center), Wan-Ting Chang, Wan‐Ting Chang (National Health Research Institutes), Po‐Chin Huang (0000-0002-9243-0838, National United University, corresponding author), Po-Chin Huang |
| Year | 2024 |
| Volume | 12 |
| Pages | 1396147-1396147 |
| Publication date | 2024-05-23 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Frontiers in Public Health (JOURNAL) |
| Journal identifiers | ISSN: 2296-2565 • E-ISSN: 2296-2565 |
| Publisher | Frontiers Media SA (PUBLISHER • CH) |
| DOI | 10.3389/fpubh.2024.1396147 |
| PMID | 38846618 |
| OpenAlex | W4398278896 |
| Language | EN |
| Citations received | 1 |
| References cited | 103 |
Introduction: Ever since the use of bisphenol A (BPA) has been restricted, concerns have been raised regarding the use of its substitutes, such as bisphenol S (BPS) and bisphenol F (BPF). Meanwhile, the EU European Food Safety Authority (EFSA) issued the new tolerable daily intake (TDI) after the latest re-risk assessment for BPA, which enforced the need for cumulative risk assessment in the population. This study was conducted to identify BPA and its substitute's exposure characteristics of the general Taiwanese population and estimate the cumulative risk of bisphenol exposure. Methods: = 366 [adult, 271; minor, 95]) were collected from individuals who participated in the Taiwan Environmental Survey for Toxicants 2013. The samples were analyzed for BPA, BPS, and BPF through ultraperformance liquid chromatography-tandem mass spectrometry. Daily intake (DI) levels were calculated for each bisphenol. Hazard quotients (HQs) were calculated with the consideration of tolerable DI and a reference dose. Additionally, hazard index (HI; sum of HQs for each bisphenol) values were calculated. Results: < 0.001). The DI of BPS was higher in female (0.69 ng/kg/day) than in male (0.49 ng/kg/day); however, the DIs of BPF and BPS were higher in boys (1.15 and 0.26 ng/kg/day, respectively) than in girls (0.57 and 0.20 ng/kg/day, respectively). Most HI values exceeded 1 (99% of the participants) after EFSA re-establish the TDI of BPA. Discussion: Our study revealed that the exposure profiles and risk of BPA and its substitute in Taiwanese varied by age and sex. Additionally, the exposure risk of BPA was deemed unacceptable in Taiwan according to new EFSA regulations, and food contamination could be the possible source of exposure. We suggest that the risk of exposure to BPA and its substitutes in most human biomonitoring studies should be reassessed based on new scientific evidence
Animal science · Biology · Bisphenol · Bisphenol A · Bisphenol S · Body weight · Confidence interval · Creatinine · Environmental health · Exposure assessment · Hazard quotient · Hazard ratio · Health risk · Population · Reference dose · Risk assessment · Tolerable daily intake · Urine · Chemistry · Effects and risks of endocrine disrupting chemicals · Medicine · Microplastics and Plastic Pollution · Pharmaceutical and Antibiotic Environmental Impacts · Internal Medicine · Toxicology
| Citations per year | 1 |
|---|---|
| Citation span | 2025 - 2025 (1) |
| Highly cited | No |