Global, regional and national burden of depressive disorders in adolescents and young adults, 1990–2021

Systematic analysis of the global burden of disease study 2021

Bibliographic Data

ID22075656
AuthorsLe Zhao (0009-0009-6032-4473), Zhao Le (Hangzhou Normal University), Yan Lou (0000-0002-7302-5132, Hangzhou Normal University), Yuexian Tao (Hangzhou Normal University, corresponding author), Hangsai Wang (Jinhua University of Vocational Technology), Nan Xu Rattanasone (0000-0002-2916-8435, Quzhou College of Technology), Nan Xu (0000-0002-6731-0615)
Year2025
Volume13
Pages1599602-1599602
Publication date2025-06-11
Peer ReviewedYes
Open AccessYes
TypeARTICLE
VenueFrontiers in Public Health (JOURNAL)
Journal identifiersISSN: 2296-2565 • E-ISSN: 2296-2565
PublisherFrontiers Media SA (PUBLISHER • CH)
DOI10.3389/fpubh.2025.1599602
PMID40567978
OpenAlexW4411221895
LanguageEN
Citations received2
References cited41

Background: To promote evidence-based policymaking, this research attempts to investigate global trends in depressive disorders among individuals aged 15-39 from 1990 to 2021, determine risk factors, and forecast the next trends from 2022 to 2050. Methods: Data from the Global Burden of Disease (GBD) 2021 database were analyzed to look at the global, national, and regional burden of depressive disorders among individuals aged 15-39 from 1990 to 2021. Incidence rates, disability-adjusted life years (DALYs), and contributions of various risk factors to DALYs were also examined in this research. All incidence and disability-adjusted life year (DALY) rates were calculated per 100,000 population and are presented with corresponding 95% uncertainty intervals (UIs). The burden of disease through 2050 was projected using Bayesian age-period-cohort (BAPC) modeling. Results: Globally, the incidence in 2021 was estimated at 158,696,139.89 cases (95% UI, 129,182,271.23-197,238,491.78), with associated DALYs totaling 25,093,054.94 (95% UI, 16,739,757.06-35,139,293.90). Between 1990 and 2021, the incidence rose by 62.91% (95% UI, 57.91-68.12%), while DALYs increased by 60.46% (95% UI, 55.99-64.91%). The highest estimated annual percentage changes (EAPCs) for both incidence [2.63%; 95% confidence interval (CI), 2.45-2.82%] and DALYs (2.72%; 95% CI, 2.57-2.88%) were identified in low Socio-demographic Index (SDI) regions. Western Europe had the most cases (9,939,816.39; 95% UI, 8,081,380.82-12,409,843.00) among the 21 geographic regions examined in 2021. Globally, India exhibited the most significant burden in 2021, with incident cases reaching 32,241,303.32 (95% UI, 26,251,449.50-39,943,511.76). Furthermore, the largest burden of DALYs was observed in India, amounting to 5,034,818.12 (95% UI, 3,363,390.70-7,076,632.70). The global burden was primarily attributed to several significant risk factors, including exposure to behavioral risks, experiences of bullying victimization, incidents of childhood sexual abuse, experiences of childhood sexual abuse and bullying, as well as intimate partner violence. Projections extending to 2050 indicate an ongoing upward trend in the incidence rate within this demographic group during this period. Conclusion: Overall, the burden of depressive disorders in this population has shown a marked increase, especially in low-SDI regions. A comprehensive understanding of the epidemiology of depressive disorders among adolescents and young adults is essential to enhance disease prevention and control efforts

Burden of disease · Disease · Disease burden · Environmental health · Global health · MEDLINE · Political science · Psychiatry · Public health · Young adult · Child and Adolescent Psychosocial and Emotional Development · Childhood Cancer Survivors' Quality of Life · Medicine · Mental Health Treatment and Access · Gerontology

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