The incidence and risk factors of selected drug prescriptions and outpatient care after Sars-CoV-2 infection in low-risk subjects

A multicenter population-based cohort study

Bibliographic Data

ID22076050
AuthorsCarlo Gagliotti (0000-0003-0684-731X, Agenzia Sanitaria e Sociale Regionale), Federico Banchelli (0000-0003-0499-2505, Agenzia Sanitaria e Sociale Regionale, corresponding author), Angela De Paoli (0000-0001-9864-6325), Rossella Buttazzi (Agenzia Sanitaria e Sociale Regionale), Elena Narne (0000-0002-4304-4789), Enrico Ricchizzi (0000-0002-9976-9359, Agenzia Sanitaria e Sociale Regionale), Elena Schievano (0000-0002-9912-5107), Stefania Bellio (0000-0003-2293-5192), Gisella Pitter, Michele Tonon (0000-0002-4917-404X), Lorenzo Maria Canziani (0000-0003-2537-5418, University of Verona), Maurizia Rolli (Agenzia Sanitaria e Sociale Regionale), Evelina Tacconelli (0000-0003-2010-4977, University of Verona), Elena Berti (0000-0001-6164-3550, Agenzia Sanitaria e Sociale Regionale), Francesca Russo (0000-0002-1120-8953), Maria Luisa Moro (0000-0003-3586-977X, Agenzia Sanitaria e Sociale Regionale)
Year2023
Volume11
Pages1241401-1241401
Publication date2023-10-04
Open AccessYes
TypeARTICLE
VenueFrontiers in Public Health (JOURNAL)
Journal identifiersISSN: 2296-2565 • E-ISSN: 2296-2565
PublisherFrontiers Media SA (PUBLISHER • CH)
DOI10.3389/fpubh.2023.1241401
PMID37860802
OpenAlexW4387335631
LanguageEN
References cited28

Background: Knowledge about the dynamics of transmission of SARS-CoV-2 and the clinical aspects of COVID-19 has steadily increased over time, although evidence of the determinants of disease severity and duration is still limited and mainly focused on older adult and fragile populations. Methods: The present study was conceived and carried out in the Emilia-Romagna (E-R) and Veneto Regions, Italy, within the context of the EU's Horizon 2020 research project called ORCHESTRA (Connecting European Cohorts to increase common and effective response to SARS-CoV-2 pandemic) (www.orchestra-cohort.eu). The study has a multicenter retrospective population-based cohort design and aimed to investigate the incidence and risk factors of access to specific healthcare services (outpatient visits and diagnostics, drug prescriptions) during the post-acute phase from day-31 to day-365 after SARS-CoV-2 infection, in a healthy population at low risk of severe acute COVID-19. The study made use of previously recorded large-scale healthcare data available in the administrative databases of the two Italian Regions. The statistical analysis made use of methods for competing risks. Risk factors were assessed separately in the two Regions and results were pooled using random effects meta-analysis. Results: There were 35,128 subjects in E-R and 88,881 in Veneto who were included in the data analysis. The outcome (access to selected health services) occurred in a high percentage of subjects in the post-acute phase (25% in E-R and 21% in Veneto). Outpatient care was observed more frequently than drug prescriptions (18% vs. 12% in E-R and 15% vs. 10% in Veneto). Risk factors associated with the outcome were female sex, age greater than 40 years, baseline risk of hospitalization and death, moderate to severe acute COVID-19, and acute extrapulmonary complications. Conclusion: The outcome of interest may be considered as a proxy for long-term effects of COVID-19 needing clinical attention. Our data suggest that this outcome occurs in a substantial percentage of cases, even among a previously healthy population with low or mild severity of acute COVID-19. The study results provide useful insights into planning COVID-19-related services

Cohort · Cohort study · Disease · Environmental health · Geography · Health care · Medical prescription · Pandemic · Population · COVID-19 Clinical Research Studies · Long-Term Effects of COVID-19 · Medicine · Pharmacological Receptor Mechanisms and Effects · Internal Medicine · Pediatrics

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