Sarcopenia index based on serum creatinine and cystatin C is associated with mortality in middle-aged and older adults in Chinese

A retrospective cohort study from the China Health and Retirement Longitudinal Study

Bibliographic Data

ID22076285
AuthorsYang Wu (0000-0002-0014-603X, First Affiliated Hospital of Xi'an Jiaotong University), Hai Wang (0000-0002-9260-3428, First Affiliated Hospital of Xi'an Jiaotong University), Yingmu Tong (First Affiliated Hospital of Xi'an Jiaotong University), Xing Zhang (0000-0002-0796-4940, First Affiliated Hospital of Xi'an Jiaotong University), Yunxiang Long (First Affiliated Hospital of Xi'an Jiaotong University), Qinglin Li (0000-0003-3002-1702, First Affiliated Hospital of Xi'an Jiaotong University), Jie Ren (0000-0001-9135-475X, First Affiliated Hospital of Xi'an Jiaotong University), Chang Liu (0000-0002-1198-6990, First Affiliated Hospital of Xi'an Jiaotong University, corresponding author)
Year2023
Volume11
Pages1122922-1122922
Publication date2023-03-21
Peer ReviewedYes
Open AccessYes
TypeARTICLE
VenueFrontiers in Public Health (JOURNAL)
Journal identifiersISSN: 2296-2565 • E-ISSN: 2296-2565
PublisherFrontiers Media SA (PUBLISHER • CH)
DOI10.3389/fpubh.2023.1122922
PMID37026117
OpenAlexW4328104923
LanguageEN
Citations received1
References cited19

Background The sarcopenia index (SI, serum creatinine/serum cystatin C × 100) is recommended for predicting sarcopenia. There were several studies showing that lower SI is associated with poorer outcomes in the older adults. However, the cohorts studied in these researches were mainly patients hospitalized. The aim of this study was to evaluate the correlation between SI and all-cause mortality among middle-aged and older adults from the China Health and Retirement Longitudinal Study (CHARLS). Materials and methods A total of 8,328 participants meeting the criteria were enrolled in this study from CHARLS between 2011 and 2012. SI was calculated as [serum creatinine (mg/dL)/cystatin C (mg/L)] × 100. Mann-Whitney U -test and Fisher's exact test were used to assess balance in baseline characteristics. Kaplan-Meier, log-rang analysis, univariate and multivariate Cox hazard ratio regression models were used to compare the mortality between different SI levels. The dose relationship between sarcopenia index and all-cause mortality was further assessed by the cubic spline functions and smooth curve fitting. Results After adjustment for potential covariates, we found SI was significantly correlated with all-cause mortality [Hazard Ratio (HR) = 0.983, 95% confidence interval (CI) 0.977–0.988, P < 0.001]. Similarly, as SI was used as a categorical variable according to quartiles, higher SI was associated with lower mortality [Hazard Ratio (HR) = 0.44, 95% CI 0.34–0.57, P < 0.001] after adjustment for confounders. Conclusions Lower sarcopenia index was associated with higher mortality among middle-aged and older adults in China

Body mass index · Confidence interval · Confounding · Creatinine · Cystatin C · Hazard ratio · Longitudinal study · Proportional hazards model · Quartile · Sarcopenia · Chronic Kidney Disease and Diabetes · Demography · Dialysis and Renal Disease Management · Medicine · Nutrition and Health in Aging · Internal Medicine

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