Negative Association Between Smoking and Positive Sars-CoV-2 Testing
Results From a Swiss Outpatient Sample Population
Bibliographic Data
| ID | 22076334 |
|---|---|
| Authors | Juan R Vallarta‐robledo (0000-0002-1145-9517, University of Geneva), Juan R Vallarta-Robledo, José Luís Sandoval (0000-0002-6256-7083, University Hospital of Geneva), Stéphanie Baggio (0000-0002-5347-5937, University Hospital of Geneva), Julien Salamun (University Hospital of Geneva), Frédérique Jacquérioz (0000-0002-6957-0920, University Hospital of Geneva), Hervé Spechbach (0000-0001-7383-8531, University Hospital of Geneva), Idris Guessous (0000-0002-0491-6089, University of Geneva, corresponding author) |
| Year | 2021 |
| Volume | 9 |
| Pages | 731981-731981 |
| Publication date | 2021-11-05 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Frontiers in Public Health (JOURNAL) |
| Journal identifiers | ISSN: 2296-2565 • E-ISSN: 2296-2565 |
| Publisher | Frontiers Media SA (PUBLISHER • CH) |
| DOI | 10.3389/fpubh.2021.731981 |
| PMID | 34805064 |
| OpenAlex | W3211788141 |
| Language | EN |
| Citations received | 1 |
| References cited | 20 |
To date, most of the evidence suggests that smoking is negatively associated with testing positive for SARS-CoV-2. However, evidence has several methodological limitations. Using an outpatient sample population, we analyzed the association of testing positive for SARS-CoV-2 and smoking considering comorbidities, socioeconomic and demographic factors. Baseline data were obtained from a cohort during the first wave of the pandemic in Geneva, Switzerland (March-April 2020). RT-PCR tests were carried out on individuals suspected of having SARS-CoV-2 according to the testing strategy at that time. Logistic regressions were performed to test the association of smoking and testing positive for SARS-CoV-2 and further adjusted for comorbidities, socioeconomic and demographic factors. The sample included 5,169 participants; 60% were women and the mean age was 41 years. The unadjusted OR for testing positive for SARS-CoV-2 was 0.46 (CI: 0.38–0.54). After adjustment for comorbidities, socioeconomic and demographic factors, smoking was still negatively associated with testing positive for SARS-CoV-2 (OR: 0.44; CI: 0.35–0.77). Women (OR: 0.79; CI: 0.69–0.91), higher postal income (OR: 0.97; CI: 0.95–0.99), having respiratory (OR: 0.68; CI: 0.55–0.84) and immunosuppressive disorders (OR: 0.63; CI: 0.44–0.88) also showed independent negative associations with a positive test for SARS-CoV-2. Smoking was negatively associated with a positive test for SARS-CoV-2 independently of comorbidities, socioeconomic and demographic factors. Since having respiratory or immunosuppressive conditions and being females and healthcare workers were similarly negatively associated with SARS-CoV-2 positive testing, we hypothesize that risk factor-related protective or testing behaviors could have induced a negative association with SARS-CoV-2
Cohort · Cohort study · Disease · Environmental health · Logistic regression · Pandemic · Population · Socioeconomic status · COVID-19 Clinical Research Studies · Demography · Medicine · Respiratory viral infections research · SARS-CoV-2 and COVID-19 Research · Internal Medicine
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| Citations per year | 0.25 |
|---|---|
| Citation span | 2022 - 2022 (1) |
| Highly cited | No |