Application of Structural and Functional Connectome Mismatch for Classification and Individualized Therapy in Alzheimer Disease
Bibliographic Data
| ID | 22077288 |
|---|---|
| Authors | Huixia Ren (0000-0002-2219-901X, Jinan University), Jin Zhu (0000-0003-4869-4980, Jinan University), Xiaolin Su (0009-0003-9045-7257, Jinan University), Siyan Chen (0000-0003-1257-8988, Jinan University), Silin Zeng (Jinan University), Xiaoyong Lan (Jinan University), Liang-Yu Zou, Liangyu Zou (Jinan University), Michael E Sughrue (0000-0001-5407-2585, Prince of Wales Hospital, corresponding author), Yi Guo (0000-0001-8622-2314, Jinan University, corresponding author) |
| Year | 2020 |
| Volume | 8 |
| Pages | 584430-584430 |
| Publication date | 2020-11-23 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Frontiers in Public Health (JOURNAL) |
| Journal identifiers | ISSN: 2296-2565 • E-ISSN: 2296-2565 |
| Publisher | Frontiers Media SA (PUBLISHER • CH) |
| DOI | 10.3389/fpubh.2020.584430 |
| PMID | 33330326 |
| OpenAlex | W3109097928 |
| Language | EN |
| Citations received | 1 |
| References cited | 47 |
While machine learning approaches to analyzing Alzheimer disease connectome neuroimaging data have been studied, many have limited ability to provide insight in individual patterns of disease and lack the ability to provide actionable information about where in the brain a specific patient's disease is located. We studied a cohort of patients with Alzheimer disease who underwent resting state functional magnetic resonance imaging and diffusion tractography imaging. These images were processed, and a structural and functional connectivity matrix was generated using the HCP cortical and subcortical atlas. By generating a machine learning model, individual-level structural and functional anomalies detection and characterization were explored in this study. Our study found that structural disease burden in Alzheimer's patients is mainly focused in the subcortical structures and the Default mode network (DMN). Interestingly, functional anomalies were less consistent between individuals and less common in general in these patients. More intriguing was that some structural anomalies were noted in all patients in the study, namely a reduction in fibers involving parcellations in the right anterior cingulate. Alternately, the functional consequences of connectivity loss were cortical and variable. Integrated structural/functional connectomics might provide a useful tool for assessing AD progression, while few concerns have been made for analyzing the mismatch between these two. We performed a preliminary exploration into a set of Alzheimer disease data, intending to improve a personalized approach to understanding individual connectomes in an actionable manner. Specifically, we found that there were consistent patterns of white matter fiber loss, mainly focused around the DMN and deep subcortical structures, which were present in nearly all patients with clinical AD. Functional magnetic resonance imaging shows abnormal functional connectivity different within the patients, which may be used as the individual target for further therapeutic strategies making, like non-invasive stimulation technology
Alzheimer's disease · Connectome · Connectomics · Default mode network · Diffusion MRI · Disease · Functional connectivity · Functional magnetic resonance imaging · Human Connectome Project · Magnetic resonance imaging · Neuroimaging · Pathology · Radiology · Resting state fMRI · Tractography · White matter · Advanced MRI Techniques and Applications · Advanced Neuroimaging Techniques and Applications · Computer Science · Functional Brain Connectivity Studies · Medicine · Neuroscience · Psychology
| Unique citing works | 1 |
|---|---|
| Citations per year | 0,5 |
| Citation span | 2024 - 2024 (1) |
| Citation velocity | recent |
| Highly cited | No |
| Citation types | Neutral: 1 |