Influence of Demographic Factors on Long-Term Trends of Premature Mortality and Burden Due to Liver Cancer

Findings From a Population-Based Study in Shanghai, China, 1973–2019

Datos Bibliográficos

ID22077598
AutoresZheng Luo (0000-0003-1497-9208, Shanghai University of Medicine and Health Sciences), Yongbin Zou (0000-0001-7891-8979, Chenzhou First People's Hospital), Jiaxin Xie (0000-0002-7623-5880, Army Medical University), Hui Cao (0000-0001-9715-2104, Chenzhou First People's Hospital), Yichen Chen (0000-0002-9043-6961, Fudan University), Yibo Ding (0000-0002-2544-3882, Second Military Medical University), Xiaopan Li (0000-0002-9625-478X, Fudan University, autor de correspondencia), Yang Deng (0000-0001-5807-1440, Shandong First Medical University, autor de correspondencia), Lile Wu (Affiliated Hospital of Southwest Medical University, autor de correspondencia)
Año2022
Volumen10
Páginas808917-808917
Fecha de publicación2022-02-15
Peer ReviewedSí
Open AccessSí
TipoARTICLE
RevistaFrontiers in Public Health (JOURNAL)
Identificadores de la revistaISSN: 2296-2565 • E-ISSN: 2296-2565
EditorialFrontiers Media SA (PUBLISHER • CH)
DOI10.3389/fpubh.2022.808917
PMID35242731
OpenAlexW4213364862
IdiomaEN
Citas recibidas1
Referencias citadas27

Objective Liver cancer is one of the most common causes of cancer-related death. Understanding how demographic factors influence mortality due to liver cancer is crucial for optimizing disease-control strategies. We aimed to characterize the long-term trends in the mortality and years of life lost (YLL) of liver cancer in Shanghai, China, 1973–2019, and quantitatively analyze the contributions of demographic and non-demographic factors on the mortality of liver cancer. Methods Using mortality data from the Mortality Registration System of Pudong New Area, the largest district of Shanghai with a population of permanent resident of 5.68 million, during 1973–2019, we analyzed the temporal trends for the mortality rates and YLL by Joinpoint Regression Program. The difference decomposition method was employed to estimate the increasing mortality rates related to demographic and non-demographic factors. Results A total of 21,530 deaths from liver cancer occurred from 1973 to 2019. The crude mortality rates (CMR) and age-standardized mortality rate by Segi's world standard population (ASMRW) of liver cancer were 26.73/10 5 person-years and 15.72/10 5 person-years, respectively. The CMR, ASMRW, and YLL rates of liver cancer showed significantly decreasing trends in males, females and the total population from 1973 to 2019, whereas the upward trends in the YLL were seen in males, females and the total population (all P < 0.05). A significant upward trend was observed in the increased CMR caused by demographic factors, but the changing rate caused by non-demographic factors decreased. Conclusions The CMR and ASMRW of liver cancer continually decreased although YLL increased during 1973–2019 in Pudong New Area, Shanghai. The demographic factors, especially aging, might be responsible for the increase in the mortality of liver cancer. More effective prevention strategies tailored to liver cancer are needed to further reduce its disease burden in the elderly population

Cancer · Environmental health · Life expectancy · Liver cancer · Mortality rate · Population · Years of potential life lost · Demography · Global Cancer Incidence and Screening · Hepatocellular Carcinoma Treatment and Prognosis · Insurance, Mortality, Demography, Risk Management · Medicine · Internal Medicine · Surgery