Associations between special diet and incidence risk of osteoporosis

A Mendelian randomization study

Bibliographic Data

ID22078796
AuthorsC Zhou (0000-0003-3331-2302, Shaanxi University of Chinese Medicine), Lixue Yang (0000-0002-0103-8663, Affiliated Hospital of Shaanxi University of Chinese Medicine), Ce Liu (0000-0003-2227-4363, Shaanxi University of Chinese Medicine), Hongzhong Ma (0000-0002-4034-0152, Shaanxi University of Chinese Medicine), Feng Yang (0009-0008-1432-2234, Affiliated Hospital of Shaanxi University of Chinese Medicine), Liheng Chen (0000-0002-9545-7809, Affiliated Hospital of Shaanxi University of Chinese Medicine, corresponding author)
Year2024
Volume12
Pages1364735-1364735
Publication date2024-05-30
Open AccessYes
TypeARTICLE
VenueFrontiers in Public Health (JOURNAL)
Journal identifiersISSN: 2296-2565 • E-ISSN: 2296-2565
PublisherFrontiers Media SA (PUBLISHER • CH)
DOI10.3389/fpubh.2024.1364735
PMID38873319
OpenAlexW4399156963
LanguageEN
References cited51

Introduction Osteoporosis is a prevalent challenge in clinical orthopedics, affecting a significant percentage of individuals aged 50 and above. The goal of this study was to comprehensively understand the relationships between a specialized dietary regimen and the risk of developing osteoporosis. Methods This study employed extensive genome-wide association study (GWAS) summary statistics derived from the UK Biobank. It encompassed 8 kinds of special diets and 7 datasets pertaining to osteoporosis and associated symptoms. The principal analytical approach employed was the inverse-variance weighted method. Additionally, sensitivity analysis was employed to elucidate the diverse multiplicity patterns observed in the final model. Results Our results showed that there is significant evidence that a gluten-free diet is associated with osteoporosis [odds ratio (OR): 1.080, 95% confidence interval (CI): 1.048–1.112, p = 4.23E-07)]. Furthermore, there exists a suggestive link between the three distinct dietary approaches and osteoporosis [(OR: 0.949, 95%CI: 0.929–0.970, p = 3.00E-06) for comprehensive consumption; (OR: 1.053, 95%CI: 1.018–1.089, p = 2.23E-03) for abstaining from wheat consumption; (OR: 1.036, 95%CI: 1.005–1.068, p = 1.97E-02) for abstaining from sugar consumption]. No additional correlation between the special dietary regimens and osteoporosis has been observed. Conclusion Our research has uncovered a notable correlation between a gluten-free diet and the occurrence of osteoporosis. Furthermore, it exerts a promoting influence on the onset of osteoporosis, which stands in direct contradiction to the therapeutic principles for Celiac Disease’s complications. As such, a novel association among these three elements is postulated

Biology · Confidence interval · Genetic variants · Mendelian randomization · Odds ratio · Osteoporosis · Celiac Disease Research and Management · Genetic Associations and Epidemiology · Medicine · Nutrition, Genetics, and Disease · Internal Medicine

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