Associations between peak expiratory flow and frailty in olderly individuals

Findings from the China health and retirement longitudinal study

Bibliographic Data

ID22078965
AuthorsRui Wang (0000-0001-7155-3356, Zhejiang Chinese Medical University), Wen Shi (0000-0003-1022-6639, Zhejiang Chinese Medical University), Wenlu Zhou (Zhejiang Chinese Medical University), Yawen Xu (0000-0003-2614-8700, Zhejiang Chinese Medical University), Junjie Wang (0000-0001-7953-4918, Zhejiang Chinese Medical University, corresponding author)
Year2024
Volume12
Pages1392581-1392581
Publication date2024-05-28
Open AccessYes
TypeARTICLE
VenueFrontiers in Public Health (JOURNAL)
Journal identifiersISSN: 2296-2565 • E-ISSN: 2296-2565
PublisherFrontiers Media SA (PUBLISHER • CH)
DOI10.3389/fpubh.2024.1392581
PMID38864017
OpenAlexW4399097651
LanguageEN
References cited43

Purpose: Peak Expiratory Flow (PEF) is associated with a variety of adverse health outcomes in older adults; however, the relationship between PEF and frailty remains uncertain, and this study investigated the relationship between PEF and frailty within an olderly Asian demographic. Methods: Data were sourced from the Chinese Health and Retirement Longitudinal Study (CHARLS). Individuals in the study, all 60 years or older, underwent baseline PEF assessments quantified as standardized residual (SR) percentile values. The evaluation of frailty was conducted based on the criteria established by Fried. Participants without frailty at the outset were tracked over a four-year period, during which the relationships between PEF and frailty were examined through logistic regression and discrete-time Cox regression analyses. Results: Among 5,060 participants, cross-sectional analysis revealed that the prevalence of frailty was 2-3 times higher in the lower 10-49th and < 10th SR percentile groups compared to the 80-100th SR percentile group. The longitudinal study corroborated these results, showing an adjusted hazard ratio (HR) of 2.01 (95% CI, 1.15-3.51) for PEF SR percentiles below the 10th, in contrast to those between the 80th and 100th percentiles. Conclusion: PEF independently predicts and determines frailty in older adults. Declines in PEF greater than expected are associated with the development of frailty. Subsequent studies are encouraged to delve deeper into the connection between respiratory function and frailty in diverse contexts

Confidence interval · Hazard ratio · Health and Retirement Study · Logistic regression · Longitudinal study · Lung function · Percentile · Proportional hazards model · Statistics · Demography · Dialysis and Renal Disease Management · Frailty in Older Adults · Medicine · Nutrition and Health in Aging · Gerontology · Internal Medicine

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