Global, regional and country burden of high BMI-related liver cancer among individuals aged above 70
Trends from 1990 to 2021 and projections to 2044
Bibliographic Data
| ID | 22079608 |
|---|---|
| Authors | Ke‐Jie He (0000-0001-7406-6254, Wenzhou Medical University, corresponding author), Ke-Jie He, Wanyi Shu (Wenzhou Medical University), Yanggang Hong (Wenzhou Medical University) |
| Year | 2025 |
| Volume | 13 |
| Pages | 1523578-1523578 |
| Publication date | 2025-03-20 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Frontiers in Public Health (JOURNAL) |
| Journal identifiers | ISSN: 2296-2565 • E-ISSN: 2296-2565 |
| Publisher | Frontiers Media SA (PUBLISHER • CH) |
| DOI | 10.3389/fpubh.2025.1523578 |
| PMID | 40182530 |
| OpenAlex | W4408648533 |
| Language | EN |
| References cited | 52 |
Background: Liver cancer (LC) is a major global health concern, being the fourth leading cause of cancer-related mortality. Older adults are more susceptible, though mortality rates for those over 70 are declining. However, disability from non-communicable diseases remains high. High body mass index (BMI) is a notable risk factor for LC, with high BMI-related liver cancer (HB-LC) being a major concern. Methods: This study utilized Global Burden of Disease (GBD) 2021 dataset to assess the impact of HB-LC on individuals aged 70 and older from 1990 to 2021, with forecasts extending to 2044. Disease burden across socio-demographic index (SDI) regions was evaluated using age-standardized disability-adjusted life years (DALYs). Joinpoint regression and age-period-cohort models were used to analyze DALY trends and demographic influences, and decomposition analysis assessed the effects of population aging, growth, and epidemiological shifts. Results: Our findings revealed significant geographical disparities in HB-LC mortality, with East Asia, Southeast Asia, and parts of West Africa showing the highest rates. Global HB-LC DALYs increased by 2.49% annually, with low SDI regions experiencing recent acceleration. Gender disparity persisted, with males facing a steeper rise in HB-LC burden. Age-related DALY rates peaked in the 80-89 age groups, showing complex patterns across SDI regions. Epidemiological changes primarily drove the increased HB-LC burden in high SDI regions, while population growth was more significant in low SDI regions. Conclusion: This data analysis underscores necessity for region-specific public health strategies and demographic-focused interventions, enhancing surveillance and targeting efforts to mitigate the increasing burden of HB-LC among the older adults
Body mass index · Disease burden · Environmental health · Epidemiological transition · Life expectancy · Pathology · Population · Public health · Years of potential life lost · Cancer Risks and Factors · Demography · Global Cancer Incidence and Screening · Liver Disease Diagnosis and Treatment · Medicine · Epidemiology · Gerontology
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| Highly cited | No |
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