Epidemiology and serotype distribution of Streptococcus pneumoniae carriage among influenza-like illness cases in metropolitan Vientiane, Lao PDR
A community-based cohort study
Bibliographic Data
| ID | 22079817 |
|---|---|
| Authors | Valentina Picot (Fondation Mérieux, corresponding author), Valentina Sanchez Picot, Inthalaphone Keovichith (Centre d’Infectiologie Christophe Mérieux of Laos), Phimpha Paboriboune (0000-0001-8568-8761, Centre d’Infectiologie Christophe Mérieux of Laos), Bruno Flaissier (Centre d’Infectiologie Christophe Mérieux of Laos), Mitra Saadatian‐Elahi (0000-0003-1265-8806, Lyon 1 Université), Mitra Saadatian-Elahi, James W Rudge (0000-0002-3031-3820, Mahidol University) |
| Year | 2023 |
| Volume | 11 |
| Pages | 1124016-1124016 |
| Publication date | 2023-04-20 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Frontiers in Public Health (JOURNAL) |
| Journal identifiers | ISSN: 2296-2565 • E-ISSN: 2296-2565 |
| Publisher | Frontiers Media SA (PUBLISHER • CH) |
| DOI | 10.3389/fpubh.2023.1124016 |
| PMID | 37151588 |
| OpenAlex | W4366549573 |
| Language | EN |
| Citations received | 1 |
| References cited | 24 |
Background Data on the epidemiology of Streptococcus pneumoniae among influenza-like illness (ILI) cases, particularly in low- and middle-income countries are scarce. This study assessed the prevalence, risk factors and serotype distribution of S. pneumoniae carriage among ILI cases in metropolitan Vientiane, Lao People's Democratic Republic. The 13-valent pneumococcal conjugate vaccine (PCV13) was introduced among infants in October 2013. Methods Active ILI surveillance was conducted through weekly phone calls in an open community-based cohort study (April 2015–February 2019), involving 5,690 participants from 1,142 randomly selected households. Participants reporting ILI symptoms provided a nasopharyngeal swab and answered a questionnaire. S. pneumoniae and serotype pneumococcal-positive samples were screened by Multiplex PCR assays. Chi-squared tests and generalized linear mixed models were used to test for variables associated with pneumococcal positivity. Results Among 1,621 ILI episodes, 269 (16.6%) tested positive for nasopharyngeal pneumococcal carriage, with the highest prevalence (55.4%) in children under 5 years. Pneumococcal carriage was significantly associated with concurrent detection of Hemophilus influenzae (adjusted odds ratio [aOR]: 6.93; 95% CI: 2.10–22.9) and exposure to household cigarette smoke (aOR: 1.65; 95% CI: 1.07–2.54). PCV13 serotypes accounted for 37.8% of all pneumococcal isolates. Detection of PCV13 serotypes among ILI cases aged under 5 years declined significantly between 2015/16 and 2018/19. Conclusions Community-based surveillance of S. pneumoniae among ILI cases complement surveillance at healthcare facilities to provide a more complete picture of pneumococcal carriage. Our findings contribute also to the growing body of evidence on the effects of PCV13 introduction on circulating serotypes and their potential replacement
Biology · Carriage · Cohort · Influenza-like illness · Pneumococcal conjugate vaccine · Pneumococcal infections · Serotype · Streptococcus pneumoniae · Vaccination · Influenza Virus Research Studies · Medicine · Pneumonia and Respiratory Infections · Respiratory viral infections research · Epidemiology · Immunology · Internal Medicine · Microbiology
| Citations per year | 0.33 |
|---|---|
| Citation span | 2023 - 2023 (1) |
| Highly cited | No |