Assessment of Knowledge, Attitude, and Practice of Obstetricians and Gynecologists Toward Off-Label Medicine Use in Female Reproductive Health Issues
Bibliographic Data
| ID | 22079875 |
|---|---|
| Authors | Sadia Shakeel (0000-0003-4941-3124, Dow University of Health Sciences, corresponding author), Wajiha Iffat (0000-0002-1892-8347, Dow University of Health Sciences), Ambreen Qamar (0009-0001-1818-9521, Dow University of Health Sciences), Shagufta Nesar (Sohail University), Fareeha Butt (Dow University of Health Sciences), Sobia Naseem Siddiqui (Dow University of Health Sciences), Hina Rehman (0009-0000-8066-1156, Jinnah Sindh Medical University), Anees Ur Rehman (0000-0002-2870-9009, Bahauddin Zakariya University) |
| Year | 2022 |
| Volume | 10 |
| Pages | 829339-829339 |
| Publication date | 2022-03-24 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Frontiers in Public Health (JOURNAL) |
| Journal identifiers | ISSN: 2296-2565 • E-ISSN: 2296-2565 |
| Publisher | Frontiers Media SA (PUBLISHER • CH) |
| DOI | 10.3389/fpubh.2022.829339 |
| PMID | 35400076 |
| OpenAlex | W4220657136 |
| Language | EN |
| Citations received | 1 |
| References cited | 34 |
Background Off-label medication usage (OLMU) is prevalent in the treatment of various diseases, including female reproductive health issues (FRHIs). However, there is a paucity of literature on the perspective of health professionals on this subject. The purpose of the current study was to assess gynecologists/obstetricians' knowledge, attitude and practice toward OLMU in the treatment of FRHIs. Methods The current cross-sectional study was conducted in September and October 2021, at five tertiary care hospitals (two public and three private sector), different clinics and maternity homes in a metropolitan city of Karachi, Pakistan. The target population was gynecologists, obstetricians and physicians/residents working in the ob/gyn department in various hospitals and clinical settings of Karachi. Results The overall response rate was 77.1%. The mean age of the study respondents was 36.1 ± 7.7 years; n = 85 (55.9%) respondents were working in primary patient care. The majorly reported OLMU by the respondents were clomiphene citrate in unexplained infertility ( n = 66; 43.4%), metformin to improve cycle regularity in females with polycystic ovary syndrome (PCOS) ( n = 59; 38.8%) and letrozole to induce ovulation ( n = 31; 20.4%). The majorly stated categories of OLMU were at a different dose ( n = 95; 62.5%) and at different indications than approved to treat ( n = 89; 58.5%). It was reported by the majority of the respondents ( n = 95; 62.5%) that they do not follow any guidelines or regulations for OLMU in their work setting; however, the response was statistically varied with the working organization (CI 2.14–2.93; p = 0.037) and practice area (CI 2.85–4.32; p = 0.0001) of respondents. Conclusions The present study revealed that the respondents were well-familiar with the practice of OLMU in the treatment of FRHIs. They expressed their concerns about decreasing such practices by being involved in collective decision-making procedures, and they were inclined to accept initiatives aimed at ensuring drug safety in patients
Cross-sectional study · Diabetes mellitus · Environmental health · Family medicine · Gynecology · Health care · Infertility · Polycystic ovary · Population · Pregnancy · Private sector · Public health · Reproductive health · Medicine · Nursing · Pharmaceutical industry and healthcare · Pharmaceutical studies and practices · Pregnancy and Medication Impact · Reproductive Medicine
| Citations per year | 0.33 |
|---|---|
| Citation span | 2023 - 2023 (1) |
| Highly cited | No |