Dynamics and features of transmission clusters of HIV-1 subtypes in the state of São Paulo, Brazil
Bibliographic Data
| ID | 22081082 |
|---|---|
| Authors | Victor Pimentel (0000-0002-7637-1268, corresponding author), Andrea Clemencia Pineda-Peña (0000-0003-1937-0506), Andrea Pineda-Peña, Cruz S Sebastião (0000-0003-1232-0119), João L de Paula (Instituto Adolfo Lutz), Cintia Mayumi Ahagon (0000-0001-8233-0369, Instituto Adolfo Lutz), Marta Pingarilho (0000-0002-7928-3087), Maria do Rosário Oliveira Martins (0000-0002-7941-0285), Luana Portes Ozório Coelho (0000-0001-8564-7935, Instituto Adolfo Lutz), Elaine Monteiro Matsuda (0000-0002-0254-4154, Instituto Adolfo Lutz), Daniela Alves (0000-0002-6213-7630), Ana Abecasis (0000-0002-3903-5265), Ana B Abecasis, Luis Fernando de Macedo Brígido (0000-0002-1022-7837, Instituto Adolfo Lutz) |
| Year | 2024 |
| Volume | 12 |
| Pages | 1384512-1384512 |
| Publication date | 2024-06-05 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Frontiers in Public Health (JOURNAL) |
| Journal identifiers | ISSN: 2296-2565 • E-ISSN: 2296-2565 |
| Publisher | Frontiers Media SA (PUBLISHER • CH) |
| DOI | 10.3389/fpubh.2024.1384512 |
| PMID | 38903572 |
| OpenAlex | W4399355524 |
| Language | EN |
| References cited | 43 |
Background Molecular epidemiology techniques allow us to track the HIV-1 transmission dynamics. Herein, we combined genetic, clinical and epidemiological data collected during routine clinical treatment to evaluate the dynamics and characteristics of transmission clusters of the most prevalent HIV-1 subtypes in the state of São Paulo, Brazil. Methods This was a cross-sectional study conducted with 2,518 persons living with HIV (PLWH) from 53 cities in São Paulo state between Jan 2004 to Feb 2015. The phylogenetic tree of protease/reverse transcriptase (PR/RT) regions was reconstructed by PhyML and ClusterPicker used to infer the transmission clusters based on Shimodaira–Hasegawa (SH) greater than 90% (phylogenetic support) and genetic distance less than 6%. Results Of a total of 2,518 sequences, 2,260 were pure subtypes at the PR/RT region, being B (88%), F1 (8.1%), and C (4%). About 21.2% were naïve with a transmitted drug resistance (TDR) rate of 11.8%. A total of 414 (18.3%) of the sequences clustered. These clusters were less evident in subtype B (17.7%) and F1 (15.1%) than in subtype C (40.2%). Clustered sequences were from PLWH at least 5 years younger than non-clustered among subtypes B ( p < 0.001) and C ( p = 0.037). Men who have sex with men (MSM) predominated the cluster in subtype B (51%), C (85.7%), and F1 (63.6%; p < 0.05). The TDR rate in clustered patients was 15.4, 13.6, and 3.1% for subtypes B, F1, and C, respectively. Most of the infections in subtypes B (80%), C (64%), and F1 (59%) occurred within the state of São Paulo. The metropolitan area of São Paulo presented a high level of endogenous clustering for subtypes B and C. The São Paulo city had 46% endogenous clusters of subtype C. Conclusion Our findings showed that MSM, antiretroviral therapy in Treatment-Naive (ART-naïve) patients, and HIV1-C, played an important role in the HIV epidemic in the São Paulo state. Further studies in transmission clusters are needed to guide the prevention intervention
Biology · Gene · Phylogenetic tree · Polymerase chain reaction · Reverse transcriptase · Transmission rate · Demography · HIV Research and Treatment · HIV/AIDS drug development and treatment · HIV/AIDS Research and Interventions · Medicine · Epidemiology · Genetics · Internal Medicine · Virology
| Citation velocity | historical |
|---|---|
| Highly cited | No |