A significant and persistent rise in the global burden of adolescent NAFLD and Nash estimated by BMI
Bibliographic Data
| ID | 22081552 |
|---|---|
| Authors | Xiao-Yun Lin (Fujian Medical University), Jing-Mao Li (Xiamen University), Lingyi Huang (0000-0003-2530-7300, Fujian Medical University), Ling-Yi Huang, Li-Yan Lin (0009-0006-5669-5659, Fujian Medical University), Mei-Zhu Hong, Mei‐Zhu Hong (0000-0002-1042-3838, Fujian Medical University, corresponding author), Shangeng Weng (Fujian Medical University, corresponding author), Jin‐Shui Pan (0000-0002-9586-7760, Fujian Medical University, corresponding author), Jin-Shui Pan |
| Year | 2024 |
| Volume | 12 |
| Pages | 1437432-1437432 |
| Publication date | 2024-10-25 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Frontiers in Public Health (JOURNAL) |
| Journal identifiers | ISSN: 2296-2565 • E-ISSN: 2296-2565 |
| Publisher | Frontiers Media SA (PUBLISHER • CH) |
| DOI | 10.3389/fpubh.2024.1437432 |
| PMID | 39525454 |
| OpenAlex | W4403749016 |
| Language | EN |
| References cited | 42 |
Background: Currently, there is a lack of global or even country/regional level data on adolescent non-alcoholic fatty liver disease (NAFLD) prevalence. However, an evidenced dose-dependent relationship exists between body mass index (BMI) and the risk of NAFLD. We aim to estimate the global and regional prevalence of adolescent NAFLD and related non-alcoholic steatohepatitis (NASH) based on BMI. Methods: Sigmoidal fitting curves were generated between BMI and the risk of NAFLD/NASH using the data extracted from the NHANES database. With global and regional BMI data from the NCD-RisC database, adolescent NAFLD/NASH prevalence was estimated at the international, regional, and country levels from 1975 to 2016. The prevalence of adolescent NAFLD/NASH from 2017 to 2030 was also forecasted. Results: The mean NAFLD prevalence was 15.31, and 12.68%, while the mean NASH prevalence was 2.50, and 2.47%, in boys, and girls aged 12-18, respectively. For both boys and girls, NAFLD/NASH prevalence increased with increasing BMI, and age. The global prevalence of adolescent NAFLD/NASH has gradually increased in the period from 1975 to 2016 and will maintain a similar trend between 2017 and 2030. High-income Western Countries had higher adolescent NAFLD/NASH whereas South Asia and Sub-Saharan Africa exhibited relatively lower adolescent NAFLD/NASH prevalence. The estimated annual percentage change (EAPC) of NAFLD prevalence in boys ranged from 0.72% (age 18) to 1.16% (age 12) while that in girls ranged from 0.69% (age 18) to 0.92% (age 12). EAPC of NASH prevalence in boys ranged from 1.65% (age 18) to 1.77% (age 12), and in girls from 1.48% (age 18) to 1.68% (age 12). Conclusion: The adolescent NAFLD/NASH prevalence increases year by year, and its burden varies significantly among different countries and regions. BMI is a precise predictor of NAFLD/NASH prevalence
Body mass index · Disease · Fatty liver · Nonalcoholic fatty liver disease · Nonalcoholic steatohepatitis · Sociology · Cardiovascular Disease and Adiposity · Computer Science · Demography · Diabetes, Cardiovascular Risks, and Lipoproteins · Liver Disease Diagnosis and Treatment · Medicine · Internal Medicine
| Highly cited | No |
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