Risk of peripheral facial palsy following parenteral inactivated influenza vaccination in the elderly Chinese population

Bibliographic Data

ID22082573
AuthorsTianchi Yang (0000-0002-9971-5107, Ningbo Center for Disease Control and Prevention), Rui Ma (0000-0002-3367-674X, Ningbo Center for Disease Control and Prevention), Lixia Ye (0000-0002-6201-3224, Ningbo Center for Disease Control and Prevention), Qiuhong Mei (Ningbo Center for Disease Control and Prevention), Jianmei Wang (0000-0002-1126-0612, Ningbo Center for Disease Control and Prevention), Yueyi Feng (Ningbo Center for Disease Control and Prevention), Shaoying Zhou (Ningbo Center for Disease Control and Prevention), Xingqiang Pan (Ningbo Center for Disease Control and Prevention), Danbiao Hu (Ningbo Center for Disease Control and Prevention), Dandan Zhang (0000-0003-3443-9946, Ningbo Center for Disease Control and Prevention, corresponding author)
Year2023
Volume11
Pages1047391-1047391
Publication date2023-01-24
Peer ReviewedYes
Open AccessYes
TypeARTICLE
VenueFrontiers in Public Health (JOURNAL)
Journal identifiersISSN: 2296-2565 • E-ISSN: 2296-2565
PublisherFrontiers Media SA (PUBLISHER • CH)
DOI10.3389/fpubh.2023.1047391
PMID36761129
OpenAlexW4317886269
LanguageEN
References cited29

Background: Concern about the risk of peripheral facial palsy (PFP) following vaccination is one reason for hesitancy in influenza vaccination. However, the association between the flu vaccine and PFP is still controversial, and further evidence is urgently needed. Methods: This self-controlled case series study evaluated PFP risk following inactivated influenza vaccine in the elderly using a large linked database in Ningbo, China. Relative incidence ratios (RIRs) and 95% confidence intervals (CIs) estimated using conditional Poisson regression were utilized to determine whether the risk of PFP was increased after vaccination. Results: This study included 467 episodes, which occurred in 244 females and 220 males. One hundred twenty-four episodes happened within 1-91 days after vaccination, accounting for 26.7%. The adjusted RIRs within 1-30 days, 31-60 days, 61-91 days, and 1-91 days after influenza vaccination were 0.95 (95% CI 0.69-1.30), 1.08 (95% CI 0.78-1.49), 1.01 (95% CI 0.70-1.45), and 1.00 (95% CI 0.81-1.24), respectively. Similar results were found in subgroup analyses and sensitivity analyses. Conclusions: Influenza vaccination does not increase PFP risk in the elderly population. This finding provides evidence to overcome concerns about facial paralysis after influenza vaccination

Confidence interval · Environmental health · Influenza vaccine · Poisson regression · Population · Relative risk · Vaccination · Infectious Encephalopathies and Encephalitis · Influenza Virus Research Studies · Intramuscular injections and effects · Medicine · Immunology · Internal Medicine · Pediatrics

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