The Economic Burden of Clostridioides difficile in Denmark
A Retrospective Cohort Study
Bibliographic Data
| ID | 22083027 |
|---|---|
| Authors | Uffe Christian Braae (0000-0002-2743-4584, Statens Serum Institut, corresponding author), Frederik Trier Møller (0000-0002-1059-4661, Statens Serum Institut), Rikke Ibsen (0000-0002-9008-429X), Steen Ethelberg (0000-0002-9709-356X, Statens Serum Institut), Jakob Kjellberg (0000-0003-4336-2397), Kåre Mølbak (0000-0002-3100-4990, Statens Serum Institut) |
| Year | 2020 |
| Volume | 8 |
| Pages | 562957-562957 |
| Publication date | 2020-11-26 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Frontiers in Public Health (JOURNAL) |
| Journal identifiers | ISSN: 2296-2565 • E-ISSN: 2296-2565 |
| Publisher | Frontiers Media SA (PUBLISHER • CH) |
| DOI | 10.3389/fpubh.2020.562957 |
| PMID | 33324595 |
| OpenAlex | W3109198579 |
| Language | EN |
| References cited | 22 |
Objectives: The aim of this study was to make a comprehensive economic assessment of the costs of hospital-acquired C. difficile infections (CDI). Methods: We carried out a retrospective matched cohort study utilizing Danish registry data with national coverage to identify CDI cases and matched reference patients without CDI (controls) for economic burden assessment in Denmark covering 2011–2014. Health care costs and public transfer costs were obtained from national registries, and calculated for 1 year prior to, and 2 years after index admission using descriptive statistics and regression analysis. Results: The study included 12,768 CDI patients and 23,272 matched controls. The total health care cost was significantly larger for CDI cases than controls throughout all periods. During the index admission period, cost was €12,867 per CDI case compared to €4,522 ( p €91,000 per case. The regression analysis showed that CDI adds a substantial economic burden, but only explains about 1/3 of the crude difference observed in the matched analysis. Discussion: The major economic impact of hospital-acquired CDI with complications underlines the importance of preventing complications in these patients. Our study provides an informed estimate of the potential economic gain per patient by successful intervention, which is likely to be relatively comparable across countries
Clostridioides · Cohort · Environmental health · Intensive care medicine · Retrospective cohort study · Clostridium difficile and Clostridium perfringens research · Gastrointestinal motility and disorders · Medicine · Microscopic Colitis · Internal Medicine
| Highly cited | No |
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