Application of oXiris-continuous hemofiltration adsorption in patients with sepsis and septic shock
A single-centre experience in China
Bibliographic Data
| ID | 22083074 |
|---|---|
| Authors | Yanyan Zhou (0000-0002-3343-9664, Central South University), Chenfang Wu (0000-0001-9579-4496, Central South University), Lin Ouyang (0000-0002-4109-9874, Central South University), Ying Peng (0000-0002-8801-5711, Central South University), Dingming Zhong (Central South University), Xiaohong Xiang (0000-0002-9020-9187, Central South University), Jinxiu Li (0000-0002-9479-8230, Central South University, corresponding author) |
| Year | 2022 |
| Volume | 10 |
| Pages | 1012998-1012998 |
| Publication date | 2022-09-29 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Frontiers in Public Health (JOURNAL) |
| Journal identifiers | ISSN: 2296-2565 • E-ISSN: 2296-2565 |
| Publisher | Frontiers Media SA (PUBLISHER • CH) |
| DOI | 10.3389/fpubh.2022.1012998 |
| PMID | 36249210 |
| OpenAlex | W4297999723 |
| Language | EN |
| References cited | 54 |
oXiris is a new, high-adsorption membrane filter in continuous hemofiltration adsorption to reduce the inflammatory response in sepsis. The investigators retrospectively reviewed patients with sepsis/septic shock who underwent at least one oXiris-treatment from November 2020 to March 2022. The demographic data, baseline levels before treatment, clinical datas, prognosis, and the occurrence of adverse events during treatment were recorded. 90 patients were enrolled in this study. The hemodynamic indices, sequential organ failure assessment score, lactate, inflammatory biomarkers levels were significantly improved at 12 h and 24 h after treatment. Procalcitonin and interleukin-6 reduction post-treatment of oXiris were most pronounced in infection from skin and soft tissue, urinary and abdominal cavity. Logistic regression analysis showed that pre-treatment sequential organ failure assessment score ( p = 0.034), percentage decrease in sequential organ failure assessment score ( p = 0.004), and age ( p = 0.011) were independent risk factors for intensive care unit mortality. In conclusion, oXiris-continuous hemofiltration adsorption may improve hemodynamic indicators, reduce the use of vasoactive drugs, reduce lactate level and infection indicators. Of note, oXiris improve organ function in sepsis, which may result to higher survival rate
Hemodialysis · Hemofiltration · Intensive care medicine · Intensive care unit · Logistic regression · Procalcitonin · Renal function · Sepsis · Septic shock · Hemodynamic Monitoring and Therapy · Intensive Care Unit Cognitive Disorders · Medicine · Sepsis Diagnosis and Treatment · Internal Medicine
| Highly cited | No |
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