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Mental health of caregivers for people with dementia and cerebral palsy as a key determinant of caregiver burden

A multivariable analysis

Bibliographic Data

ID22083189
AuthorsAlba Sánchez-Gil (Laboratoire National de Référence), Andrea Calleja-Caballero (Instituto de Investigación Biomédica de Salamanca), Fátima Pérez-Robledo (Universidad de Salamanca), Fátima Pérez Robledo (0000-0003-2695-0250, Instituto de Investigación Biomédica de Salamanca), Carlos Martín-Sánchez (0000-0002-8627-3645, Instituto de Investigación Biomédica de Salamanca), María Rodríguez-Lorenzo (Universidad de Salamanca), María José Rodríguez-Lorenzo (Universidad de Salamanca), María Martínez-Romo (Universidad de Salamanca), Enrique Pérez-Saez (Laboratoire National de Référence), Pedro Manuel Rodríguez-Muñoz (0000-0002-7933-952X, University of Castilla-La Mancha), Cristina Rivera-Picón (University of Castilla-La Mancha), Jesus Pérez (0000-0003-0740-190X, Instituto de Investigación Biomédica de Salamanca), Juan Luis Sánchez‐González (0000-0002-4791-6513, Universidad de Salamanca), Juan Luis Sánchez-González (Instituto de Investigación Biomédica de Salamanca)
Year2026
Volume14
Pages1757413-1757413
Publication date2026-03-04
Open AccessYes
TypeARTICLE
VenueFrontiers in Public Health (JOURNAL)
Journal identifiersISSN: 2296-2565 • E-ISSN: 2296-2565
PublisherFrontiers Media SA (PUBLISHER • CH)
DOI10.3389/fpubh.2026.1757413
PMID41859267
OpenAlexW7133495049
LanguageEN
References cited32

Background: Informal caregiving plays a vital role in supporting dependent individuals; however, prolonged caregiving is associated with significant physical and psychological strain. Understanding factors associated with caregiver burden is essential for designing effective interventions to protect caregiver health and sustain long-term care systems. Objective: To examine the associations between psychological, physical, and contextual factors on caregiver burden and to identify variables independently associated with caregiver burden. Methods: A cross-sectional study was conducted with 73 informal caregivers of people living with dementia or cerebral palsy who required substantial assistance in daily living. Standardized instruments were used to assess caregiver burden (Zarit Burden Interview), anxiety and depression (HADS), mental health and quality of life (SF-36), pain (VAS), and physical activity (IPAQ). Hierarchical multiple regression, mediation, and moderation analyses were performed. Results: = 0.049, respectively), followed by musculoskeletal pain in the back and lower limbs. Patient-related variables, such as functional dependence or disability, were not directly associated with burden. Mediation analysis showed that mental health did not mediate the dependence-burden link. Moderation analysis did not reveal a statistically significant interaction effect. The final model explained over 60% of the variance in caregiver burden. Conclusion: Caregiver mental health is a key determinant of perceived burden of caring for people with dementia and cerebral palsy, exerting a stronger influence than patient dependence or physical demands. Interventions should integrate psychological screening and mental health support to prevent caregiver distress and ensure a sustainable informal care

Anxiety · Caregiver burden · Cerebral palsy · Dementia · Mediation · Mental health · Moderation · Psychological intervention · Dementia and Cognitive Impairment Research · Family and Disability Support Research · Family Caregiving in Mental Illness

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