Using the exploration, preparation, implementation, sustainment (Epis) framework to assess the cooperative re-engagement controlled trial (CoRect)

Background: "Data to Care" (D2C) is a strategy which relies on a combination of public health surveillance data supplemented by clinic data to support continuity of HIV care. The Cooperative Re-Engagement Controlled Trial (CoRECT) was a CDC-sponsored randomized controlled trial of a D2C model, which provided an opportunity to examine the process of implementing an intervention for people with HIV (PWH) who are out-of-care across three public health department jurisdictions. Using the EPIS (Exploration, Preparation, Implementation, Sustainment) framework, we aimed to retrospectively describe the implementation process for each site to provide insights and guidance to inform future D2C activities implemented by public health agencies and their clinical and community partners. Methods: After completion of CoRECT, the three (Connecticut, Massachusetts, Philadelphia) trial sites reviewed study protocols and held iterative discussions to describe and compare their processes regarding case identification, interactions with partnering clinics and patients, and sustainability. The EPIS framework provided a structure for comparing key organizational and operational practices and was applied to the entire implementation process. Results: The trial sites varied in their implementation processes and the specific elements of the intervention. Factors including prior D2C experience, data management and analytic infrastructure, staff capacity, and relationships with clinic partners informed intervention development and implementation. Additionally, this review identified key lessons learned including to: (1) explore new supplemental sources for public health surveillance data; (2) work with stakeholders representing core functions/components in the early stages of the intervention design process; (3) build flexibility into all components of the follow-up activities; and (4) integrate data sharing, project management, and follow-up activities within existing DPH organizational structure. Conclusion: The CoRECT study provides a general blueprint and lessons learned for implementing a D2C intervention for re-engagement in HIV care. Interventions should be tailored to local operational and structural factors, and responsive to evolving clinical and public health practices

Business · Community engagement · Health care · Political science · Process management · Public health · Public relations · Randomized controlled trial · Computer Science · Health Policy Implementation Science · HIV/AIDS Research and Interventions · Medicine · Mental Health and Patient Involvement · Nursing

• Disease Intervention Specialist Field Experience in Re-engaging Out-of-Care People with HIV in Project CoRect

  Open Access•Eteri Machavariani, Frederick L Altice et al.•AIDS and Behavior•2025

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• Predictors of HIV Care Outcomes among Recently Out-of-Care Individuals in The Massachusetts Cooperative Re-engagement Controlled Trial Cohort

  Open Access•Dinesh Binod Pokhrel, Simona G Lang et al.•AIDS and Behavior•2024

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• Systematic review of the Exploration, Preparation, Implementation, Sustainment (Epis) framework

  Open Access•Joanna C Moullin, Kelsey S Dickson et al.•Implementation Science•2019

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• Using HIV Surveillance Laboratory Data to Identify Out-of-Care Patients

  Open Access•John Christian Hague, Betsey John et al.•AIDS and Behavior•2017

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• A Systematic Review of Strategies for Implementing Empirically Supported Mental Health Interventions

  Open Access•Byron J Powell, Enola K Proctor et al.•Research on Social Work Practice•2014

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